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Data
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Criticality,degeneracy in injury-induced changes in primary afferent excitability (Ratte et al 2014)
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"Neuropathic pain remains notoriously difficult to treat despite numerous drug targets. Here, we offer a novel explanation for this intractability. Computer simulations predicted that qualitative changes in primary afferent excitability linked to neuropathic pain arise through a switch in spike initiation dynamics when molecular pathologies reach a tipping point (criticality), and that this tipping point can be reached via several different molecular pathologies (degeneracy). ..."
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Neuron or other electrically excitable cell Show
Other
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Ratté S, Zhu Y, Lee KY, Prescott SA (2014) Show
Other
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tom.morse@yale.edu
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Ratte et al 2014
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