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Data
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Origin of heterogeneous spiking patterns in spinal dorsal horn neurons (Balachandar & Prescott 2018)
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"Neurons are often classified by spiking pattern. Yet, some
neurons exhibit distinct patterns under subtly different test
conditions, which suggests that they operate near an abrupt
transition, or bifurcation. A set of such neurons may exhibit
heterogeneous spiking patterns not because of qualitative
differences in which ion channels they express, but rather
because quantitative differences in expression levels cause
neurons to operate on opposite sides of a bifurcation. Neurons in
the spinal dorsal horn, for example, respond to somatic current
injection with patterns that include tonic, single, gap, delayed
and reluctant spiking. It is unclear whether these patterns
reflect five cell populations (defined by distinct ion channel
expression patterns), heterogeneity within a single population,
or some combination thereof. We reproduced all five spiking
patterns in a computational model by varying the densities of a
low-threshold (KV1-type) potassium conductance and an
inactivating (A-type) potassium conductance and found that
single, gap, delayed and reluctant spiking arise when the joint
probability distribution of those channel densities spans two
intersecting bifurcations that divide the parameter space into
quadrants, each associated with a different spiking
pattern.
...
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tom.morse@yale.edu
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Balachandar and Prescott 2018
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