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  Data
Dentate gyrus granule cell
Lomo, Patterns of activation in a monosynaptic cortical pathway: The perforant path input to the dentate area of the hippcampal formation, Experimental Brain Research, 1971 12:46-63.
90
399,122
The principal neuron of the fascia dentata of the hippocampal region. It forms a single layer of cell bodies. Each cell has a dendritic tree that extends toward the surface. The branches are covered with dendritic spines. The input is carried by axons which arise in the nearby entorinal cortex and "perforate" the intervening cortex to make excitatory glutamatergic synapses onto the spines. The output is carried in an axon which becomes a mossy fiber as it arrives in CA3 and CA2 of the hippocampus to make glutamatergic synapes onto the spinous excrecenses of hippocampal pyramidal cells in those regions.
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 Neuronal Receptors (23)
  
SN Property present CF-Compartment Receptor Connect Note References Notes Publication facts
1 Yes Distal equivalent dendrite NMDA Perforant path terminals
2 Yes Distal equivalent dendrite AMPA Perforant path terminals
3 Yes Distal equivalent dendrite mGluR Perforant path terminals
4 Yes Distal equivalent dendrite GabaA Hilar spiny interneuron terminals
5 Yes Distal equivalent dendrite GabaB Hilar spiny interneuron terminals
6 Yes Middle equivalent dendrite AMPA Perforant path terminals
7 Yes Middle equivalent dendrite mGluR Perforant path terminals
8 Yes Middle equivalent dendrite GabaA Hilar spiny and aspiny interneuron terminals
9 Yes Middle equivalent dendrite NMDA Perforant path terminals
10 Yes Middle equivalent dendrite GabaB Hilar spiny and aspiny interneuron terminals
11 Yes Proximal equivalent dendrite NMDA Hilar mossy cell collaterals and commissural cell terminals
12 Yes Proximal equivalent dendrite GabaB Hilar aspiny interneuron terminals
13 Yes Proximal equivalent dendrite mGluR Hilar mossy cell collaterals and commissural cell terminals
14 Yes Proximal equivalent dendrite AMPA Hilar mossy cell collaterals and commissural cell terminals
15 Yes Proximal equivalent dendrite GabaA Hilar aspiny interneuron terminals
16 Yes Axon hillock GabaA Chandelier cell terminals
17 Yes Axon hillock GabaB Chandelier cell terminals
18 Yes Soma GabaA Basket cell terminals Whole cell and perforated patch recordings in slices showed bicuculline-dependent and ?independent GABA currents from juvenile rats, suggesting two types of GABAergic inputs. The bicuculline-independent component was present only at the earliest stages of maturation, had a later peak, slower time course of decay, and marked outward rectification. A trophic or signaling role rather than primarily inhibitory was suggested for this current (>201<). Whole cell and perforated patch recordings in slices showed bicuculline-dependent and ?independent GABA currents from juvenile rats, suggesting two types of GABAergic inputs. The bicuculline-independent component was present only at the earliest stages of maturation, had a later peak, slower time course of decay, and marked outward rectification. A trophic or signaling role rather than primarily inhibitory was suggested for this current >201<
19 Yes Soma AMPA NMDA and AMPA conductances properties were studied using patch-clamp recordings in morphologically identified cells in slices prepared from surgically removed medial temporal lobe specimens of epileptic patients (14 specimens from 14 patients (>206<). NMDA and AMPA conductances properties were studied using patch-clamp recordings in morphologically identified cells in slices prepared from surgically removed medial temporal lobe specimens of epileptic patients (14 specimens from 14 patients >206<
20 Yes Soma NMDA NMDA and AMPA conductances properties were studied using patch-clamp recordings in morphologically identified cells in slices prepared from surgically removed medial temporal lobe specimens of epileptic patients (14 specimens from 14 patients). The wide range of changes in the slope conductance of the NMDA EPSCs suggests that the NMDA-receptor-mediated conductance could be altered in human epileptic DGCs (>206<). NMDA and AMPA conductances properties were studied using patch-clamp recordings in morphologically identified cells in slices prepared from surgically removed medial temporal lobe specimens of epileptic patients (14 specimens from 14 patients). The wide range of changes in the slope conductance of the NMDA EPSCs suggests that the NMDA-receptor-mediated conductance could be altered in human epileptic DGCs >206<
21 Yes Soma GabaB Basket cell terminals
22 Yes Soma Nicotinic
23 Yes Axon terminal Kainate It has been shown that activation of these receptors could facilitate transmitter release. Their activation is very fast (<10 ms) and lasts for seconds, and could contribute to the short-term plasticity characteristics of mossy fiber synapses (>281<). It has been shown that activation of these receptors could facilitate transmitter release. Their activation is very fast (<10 ms) and lasts for seconds, and could contribute to the short-term plasticity characteristics of mossy fiber synapses >281<
 Neuronal Currents (23)
  
SN Property present CF-Compartment Current Connect Note References Notes Publication facts
1 Yes Distal equivalent dendrite I Na,t
2 Yes Distal equivalent dendrite I A
3 Yes Distal equivalent dendrite I L high threshold
4 Yes Distal equivalent dendrite I Na,p low density low density
5 Yes Middle equivalent dendrite I L high threshold
6 Yes Middle equivalent dendrite I Na,p low density low density
7 Yes Proximal equivalent dendrite I L high threshold
8 Yes Proximal equivalent dendrite I Na,p
9 Yes Axon hillock I K
10 Yes Axon hillock I Na,t
11 Yes Axon hillock I K,Ca
12 Yes Axon terminal I N
13 Yes Soma I K,Ca Voltage-clamp analysis suggested that IAHP in DG neurones is generated by about 1200 channels, and that about 60% are open at the peak of a maximal IAHP (>202<). Voltage-clamp analysis suggested that IAHP in DG neurones is generated by about 1200 channels, and that about 60% are open at the peak of a maximal IAHP >202<
14 Yes Soma I L high threshold Cells acutely dissociated from slices obtained from chronic temporal lobe epilepsy patients displayed a high-voltage activated Ca2+ conductance with a pronounced Ca2+-dependent inactivation (>204<). Patch-clamp recordings from human cells showed N-type, L-type and T-type currents that had similar pharmacological and kinetic characteristics as in control rats. The current density was significantly larger in human and in the kainate model compared to cells isolated from adult control rats (>205<). Patch-clamp recordings from human cells showed N-type, L-type and T-type currents that had similar pharmacological and kinetic characteristics as in control rats. The current density was significantly larger in human and in the kainate model compared to cells isolated from adult control rats >205<
15 Yes Soma I N Patch-clamp recordings from human cells showed N-type, L-type and T-type currents that had similar pharmacological and kinetic characteristics as in control rats. The current density was significantly larger in human and in the kainate model compared to cells isolated from adult control rats (>205<). Patch-clamp recordings from human cells showed N-type, L-type and T-type currents that had similar pharmacological and kinetic characteristics as in control rats. The current density was significantly larger in human and in the kainate model compared to cells isolated from adult control rats >205<
16 Yes Soma I T low threshold Patch-clamp recordings from human cells showed N-type, L-type and T-type currents that had similar pharmacological and kinetic characteristics as in control rats. The current density was significantly larger in human and in the kainate model compared to cells isolated from adult control rats (>205<). Patch-clamp recordings from human cells showed N-type, L-type and T-type currents that had similar pharmacological and kinetic characteristics as in control rats. The current density was significantly larger in human and in the kainate model compared to cells isolated from adult control rats >205<
17 Yes Soma I A Properties of potassium outward currents were investigated from 11 specimens obtained from patients with temporal lobe epilepsy. An IK but not IA or inwardly rectifying potassium currents, were observed in all cells (>207<). The properties of outward currents were investigated with patch-clamp in acutely isolated cells at various postnatal ages and at adulthood (2-3 mo). Kinetic analysis and pharmacological properties showed that IK and IA were present in these cells. IA and IK remained stable with respect to kinetic properties during ontogenesis, but the relative contribution and pharmacological properties varied with age. IA dominated in P5-7 cells whereas IK was prominent in most older cells (>208<). The properties of outward currents were investigated with patch-clamp in acutely isolated cells at various postnatal ages and at adulthood (2-3 mo). Kinetic analysis and pharmacological properties showed that IK and IA were present in these cells. IA and IK remained stable with respect to kinetic properties during ontogenesis, but the relative contribution and pharmacological properties varied with age. IA dominated in P5-7 cells whereas IK was prominent in most older cells >208<
18 Soma I h Patch-pipette recordings found no evidence for a ?sag? in hyperpolarizing responses, suggesting that this current is not present in these neurons (>296<). Patch-pipette recordings found no evidence for a ?sag? in hyperpolarizing responses, suggesting that this current is not present in these neurons >296<
19 Yes Middle equivalent dendrite I Na,t Indirect experimental evidence for dendritic Na channels was suggested by laminar filed potential studies (>400<). Indirect experimental evidence for dendritic Na channels was suggested by laminar filed potential studies >400<
20 Yes Proximal equivalent dendrite I Na,t Indirect experimental evidence for dendritic Na channels was suggested by laminar filed potential studies (>400<). Indirect experimental evidence for dendritic Na channels was suggested by laminar filed potential studies >400<
21 Yes Soma I Na,t With whole-cell recordings the properties of a voltage-dependent Na+ currents were investigated in 42 DGC acutely isolated from the resected hippocampus of 20 patients with therapy-refractory temporal lobe epilepsy (TLE) using the whole-cell patch-clamp technique. The kinetic properties contributed to a reduction of the Na+ currents during repetitive stimulation that was more pronounced with higher stimulation frequencies and also showed a dependence on the holding potential (>203<). The kinetic properties of this current were studied using the whole-cell voltage-clamp method in acutely isolated cells. No significant differences were found after induction of status epilepticus (>295<). The kinetic properties of this current were studied using the whole-cell voltage-clamp method in acutely isolated cells. No significant differences were found after induction of status epilepticus >295<
22 Yes Soma I K Properties of K+ outward currents were investigated in human DG cells from 11 specimens obtained from patients with temporal lobe epilepsy. An IK was observed in all cells. The average current density, the time-dependent decay, and the resting membrane characteristics were not significantly different between patients with and without Ammon Horn Sclerosis. The V1/2(inact) was shifted in a hyperpolarizing direction in AHS (-67.7mV) compared with that in hippocampi not showing AHS (-47.7mV) (>207<). The properties of outward currents were investigated with patch-clamp in acutely isolated rat DGCs at various postnatal ages and at adulthood (2-3 mo). Kinetic analysis and pharmacological properties showed that IK and IA were present in these cells. IA and IK remained stable with respect to kinetic properties during ontogenesis, but the relative contribution and pharmacological properties varied with age. IA dominated in P5-7 cells whereas IK was prominent in most older cells (>208<). The properties of outward currents were investigated with patch-clamp in acutely isolated rat DGCs at various postnatal ages and at adulthood (2-3 mo). Kinetic analysis and pharmacological properties showed that IK and IA were present in these cells. IA and IK remained stable with respect to kinetic properties during ontogenesis, but the relative contribution and pharmacological properties varied with age. IA dominated in P5-7 cells whereas IK was prominent in most older cells >208<
23 Yes Axon terminal I L high threshold Transients and kinetics for these channels were studied using whole-cell patch clamp recordings (>475<). Transients and kinetics for these channels were studied using whole-cell patch clamp recordings >475<
 Neuronal Transmitters (6)
  
SN Property present CF-Compartment transmitter Connect Note References Notes Publication facts
1 Yes Axon terminal Zn2+ CA3 pyramidal neuron proximal dendrites, mossy cell proximal dendrites, and basket cell basal dendrites
2 Yes Axon terminal Glutamate CA3 pyramidal neuron proximal dendrites, mossy cell proximal dendrites, and basket cell basal dendrites
3 Yes Distal equivalent dendrite Dynorphin Perforant path terminals
4 Yes Axon terminal Dynorphin CA3 pyramidal neuron proximal dendrites, mossy cell proximal dendrites, and basket cell basal dendrites
5 Yes Middle equivalent dendrite Dynorphin Perforant path terminals
6 Yes Axon fiber Glutamate To presynaptic kainate receptors in the CA3 region of the hippocampus Glutamate - kainate receptor (glur6)In mouse hippocampal slices, bath application of kainate caused presynaptic reduction in epscs at mossy fiber synapses on CA3 pyramidal cells in glur6 knockouts but not in glur5 knockouts.(>176<) Glutamate - kainate receptor (glur6)In mouse hippocampal slices, bath application of kainate caused presynaptic reduction in epscs at mossy fiber synapses on CA3 pyramidal cells in glur6 knockouts but not in glur5 knockouts.>176<
Other categories referring to Dentate gyrus granule cell
Computational model.Model Neurons   (34)
Pathological mechanism.Neuron   (1)
2 Objects Relationship (edge).Object Two (target)   (1)
Neural compartmental intracell.Neuron   (1)
Cell Type.NeuronDB Neuron   (1)
Neuronal Structure.Neurons   (1)
Revisions: 13
Last Time: 12/18/2015 11:13:46 AM
Reviewer: System Administrator
Owner: System Administrator