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A computational model of oxytocin modulation of olfactory recognition memory (Linster & Kelsch 2019)
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Christiane Linster
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Model of olfactory bulb (OB) and anterior olfactory nucleus (AON) pyramidal cells. Includes olfactory sensory neurons, mitral cells, periglomerular, external tufted and granule interneurons and pyramidal cells. Can be built to include a feedback loop between OB and AON. Output consists of voltage and spikes over time in all neurons. Model can be stimulated with simulated odorants. The code submitted here has served for a number of modeling explorations of olfactory bulb and cortex.
The model architecture is defined in "bulb.dat" with synapses defined in "channels.dat". The main function to run the model can be found in "neuron.c". Model architecture is constructed in "set.c" from types defined in "sim.c". A make file to create an executable is located in "neuron.mak".
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Olfactory bulb main mitral GLU cell Show
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Olfactory bulb main interneuron periglomerular GABA cell Show
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Olfactory bulb main interneuron granule MC GABA cell Show
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Olfactory bulb main interneuron granule TC GABA cell Show
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Olfactory bulb main tufted cell external Show
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LinsterKelsch2019
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Linster, Christiane [cl243 at cornell.edu] Show
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cl243@cornell.edu
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Christiane Linster
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Cleland, TA., and Linster C. (2012) On-center/inhibitory surround decorrelation vai intraglomerular inhibition in the olfactory bulb glomerular layer. Front Integr Neurosc. 6:5.
Linster, C. Nai, Q. and Ennis, M. (2011) Non-linear effects of noradrenergic modulation of olfactory bulb function in adult rodents. J. Neurophysiol. 105(4):1432-43.
Linster, C. and Cleland, TA. (2011) Decorrelation of odor respresentations via spike timing dependent plasticity. Frontiers in Computational Neuroscience. 4: 157.
Escanilla, O., Arrellanos, A., Karnow, A., Ennis, M. and Linster, C. (2010) Noradrenergic modulation of odor detection and discrimination thresholds. Eur J Neuroscience 32(3):458-68.
Linster, C., Menon, AV, Singh, CY, Wilson, DA (2009) Odor specific habituation arises from interaction of afferent synaptic adaptation and intrinsic synaptic potentiation in olfactory cortex. Learn Mem. 16)7): 452-9
Linster and Cleland (2004) Configurational and elemental olfactory mixture perception can arise from lateral inhibition J Comput Neurosci. 16(1):39-47.
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