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Hippocampus CA1 pyramidal GLU cell
cell <a href="http://neuromorpho.org/neuroMorpho/neuron_info.jsp?neuron_name=c91662">91662</a> in <a href="http://neuromorpho.org">NeuroMorpho.org</a>.
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234,-15
The principal neuron of region CA1 of the hippocampus. It gives rise to an apical dendrite and several basal dendrites, which are covered with spines. The spines receive glutamatergic synapses from the axons (Schafer collaterals) pyramidal neurons in the CA3 region of the hippocampus. A number of different kinds of interneurons make inhibitory GABAergic synapses at different levels in the dendritic trees. The output is carried in the axon to the nearby subiculum and into the fimbria, to make eventual connection with the mamillary body of the hypothalamus
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 Neuronal Receptors (35)
  
SN Property present CF-Compartment Receptor Connect Note Publication facts
1 Yes Distal apical dendrite NMDA Recordings from membrane patches of dendrites and soma reveal fast and slow responses to fast application of glutamate, mediated by AMPA and NMDA receptors, respectively
2 Yes Distal apical dendrite Gaba --- cited in Johnston and Amaral, 1998).
3 Yes Middle oblique dendrite Glutamate Shaffer collaterals (T) The CA1 oblique dendrites (also called radial oblique) are the main target of the Schaffer collaterals from CA3, and are therefore the primary sites of generation of LTP.
4 Yes Distal oblique dendrite Glutamate Shaffer collaterals (T) The CA1 oblique dendrites (also called radial oblique) are the main target of the Schaffer collaterals from CA3, and are therefore the primary sites of generation of LTP.
5 Yes Proximal apical dendrite Glutamate
6 Yes Distal basal dendrite Glutamate P2
7 Yes Middle basal dendrite Glutamate P2
8 Yes Proximal basal dendrite Glutamate
9 Yes Soma GabaB Interneuron terminals (T)
10 Yes Soma GabaA Interneuron terminals (T)
11 Yes Distal apical dendrite Glutamate Perforant pathway entorhinal pyramidal neuron terminals (T) CA1 pyramidal neurons increase their firing (recorded extracellularly) in response to ionophoresed Glu within their apical dendritic fields or in the cell body layer (Dudar 1974 PMID#4437726).
12 Yes Middle apical dendrite NMDA EM showed colocalization at axodendritic asymmetric synapses within the CA1 subfield of rat hippocampus. AMPA/NMDA receptor colocalization was found in non-GABAergic dendritic shafts as well as dendritic spines, suggesting that excitatory neuronal transmission in CA1 neurons may generally involve activation of both NMDA and AMPA receptor subunits at a single synapse
13 Yes Middle apical dendrite AMPA Using outside-out patches and a fast application system the properties and distribution of synaptic glutamate receptors an approximately twofold increase in AMPA-mediated current was observed in the dendritic region that receives a uniform density of Schaffer collateral input (100-250um from soma)
14 Yes Middle apical dendrite GabaA
15 Yes Middle apical dendrite GabaB
16 Yes Proximal apical dendrite GabaB Interneuron terminals (T)
17 Yes Proximal apical dendrite GabaA Interneuron terminals (T) GABA(A)-mediated (bicuculline-sensitive) inhibitory responses can be demonstrated in CA1 neurons by extracellular recording (Curtis et al, 1970) and by recording spontaneous synaptic currents (Collingridge, 1984).
18 Yes Distal basal dendrite GabaA Interneuron terminals (T)
19 Yes Distal basal dendrite GabaB Interneuron terminals (T)
20 Yes Middle basal dendrite GabaA Interneuron terminals (T)
21 Yes Middle basal dendrite GabaB Interneuron terminals (T)
22 Yes Proximal basal dendrite GabaB Interneuron terminals (T)
23 Yes Proximal basal dendrite GabaA Interneuron terminals (T)
24 Yes Axon hillock GabaA Interneuron terminals (T)
25 Yes Axon hillock GabaB Interneuron terminals (T)
26 Yes Middle apical dendrite mGluR --- provide evidence that activation of these receptors is necessary for LTP induction .
27 Yes Distal apical dendrite AMPA Recordings from membrane patches of dendrites and soma reveal fast and slow responses to fast application of glutamate, mediated by AMPA and NMDA receptors, respectively
28 Yes Middle apical dendrite Glutamate
29 Yes Proximal apical dendrite AMPA EM showed colocalization at axodendritic asymmetric synapses within the CA1 subfield of rat hippocampus. AMPA/NMDA receptor colocalization was found in non-GABAergic dendritic shafts as well as dendritic spines, suggesting that excitatory neuronal transmission in CA1 neurons may generally involve activation of both NMDA and AMPA receptor subunits at a single synapse
30 Yes Proximal apical dendrite NMDA EM showed colocalization at axodendritic asymmetric synapses within the CA1 subfield of rat hippocampus. AMPA/NMDA receptor colocalization was found in non-GABAergic dendritic shafts as well as dendritic spines, suggesting that excitatory neuronal transmission in CA1 neurons may generally involve activation of both NMDA and AMPA receptor subunits at a single synapse
31 Yes Soma AMPA Recordings from membrane patches of dendrites and soma reveal fast and slow responses to fast application of glutamate, mediated by AMPA and NMDA receptors, respectively
32 Yes Soma NMDA Recordings from membrane patches of dendrites and soma reveal fast and slow responses to fast application of glutamate, mediated by AMPA and NMDA receptors, respectively
33 Yes Proximal apical dendrite Gaba CA1 Basket Cell terminals (T) The baskets formed by inhibitory basket cells have high concentrations of glutamic acid decarboxylase (GAD), the enzyme that synthesizes GABA
34 Yes Proximal apical dendrite mGluR --- provide evidence that activation of these receptors is necessary for LTP induction
35 Yes Soma Gaba CA1 Basket Cell terminals (T) A 40-50% reduction in a small fraction of (peri-) somatic synapses with large or complex postsynaptic structure after kindling has been found. This functionally relevant reduction may be related to the loss of a specific class of interneurons, and could underlie the enhanced seizure susceptibility after kindling epileptogenesis
 Neuronal Currents (44)
  
SN Property present CF-Compartment Current Connect Note Publication facts
1 Yes Soma I A Patch-clamp recordings reveal A-type K channels in the soma
2 Yes Distal apical dendrite I A CA1 neurons and subiculum neurons in hippoampus differ in firing pattern (the former being regular and the later being either regular, weakly bursting or strongly bursting) and resting membrane properties (such as input restistance and membran time constant); however, low concentration of 4-AP (50 ?M) can convert neurons in both regions into firing bursting action potentials
3 Yes Axon hillock I K
4 Yes Distal oblique dendrite I A Individual branches can function as single integrative compartments where the fast oblique spike contains contributions from NMDA, VGCCs, and the A current
5 Yes Middle apical dendrite I Potassium A D-type potassium current is involved in dendritic calcium spikes initiation and repolarization
6 Yes Proximal apical dendrite I Potassium CA1 neurons and subiculum neurons in hippoampus differ in firing pattern (the former being regular and the later being either regular, weakly bursting or strongly bursting) and resting membrane properties (such as input restistance and membran time constant); however, low concentration of 4-AP (50 µM) can convert neurons in both regions into firing bursting action potentials
7 Yes Soma I T low threshold T-type channels are less dense in the soma than in the dendrites
8 Yes Soma I Na,t Slow inactivation of sodium channels in dendrites and soma will modulate neuronal excitability in a way that depends in a complicated manner on the resting potential and previous history of action potential firing
9 Yes Soma I L high threshold In patch recordings, "HVA-l channels reminiscent of L-type channels were occasionally encountered primarily in the more proximal dendrites" (and in the soma)
10 Yes Soma I N Using confocal microscopy, these channels were found to be localized on the soma, dendrites, and a subpopulation of dendritic spines
11 Yes Soma I p,q Patch recordings indicate channels similar in basic characteristics to one or more of the HVAm channel types (most likely Q- or R-type channels)
12 Yes Soma I K The properties of voltage-gated potassium currents were studied in acutely isolated rat cells from area CA1 and CA3 at postnatal ages of day 6-8, 9-14, and 26-29 (P6-8, P9-14, and P26-29) with the use of the whole cell version of the patch-clamp technique. In CA1 cells IK was blocked by TEA at +30 mV with an IC50 of 0.98 mM. In CA3 cells the corresponding IC50 value was 1.05 mM. About 20% of IK were insensitive to TEA. IK was partially blocked by approximately 30% with 100 microM 4-AP. Mast cell degranulating peptide (100-200 nM) and dendrotoxin (50-300 nM) had no effect on IK. IK was upregulated with increasing postnatal age. This increase in the expression of IK was approximately 300% much larger in CA1 cells than in CA3 cells, with only approximately 50%
13 Yes Middle apical dendrite I A CA1 neurons and subiculum neurons in hippoampus differ in firing pattern (the former being regular and the later being either regular, weakly bursting or strongly bursting) and resting membrane properties (such as input restistance and membran time constant); however, low concentration of 4-AP (50 µM) can convert neurons in both regions into firing bursting action potentials
14 Yes Distal apical dendrite I p,q which is important for the induction of long term changes in synaptic strength"
15 Yes Distal apical dendrite I T low threshold However, in a few apical patches the channel density was increased X 3, which could indicate channel clustering. Ca fluorescence imaging shows that application of T-channel antagonists reduces the Ca influx associated with backpropagating action potentials, and has a two-fold greater effect in the soma than in the dendrites
16 Yes Distal apical dendrite I Na,t Single action potential backpropagations show dichotomy of either strong attenuation (26-42%) or weak attenuation (71-87%). The dichotomy seems to be conferred primarily by differences in distribution, density, etc. of voltage dependent sodium and potassium channel (A-type, especially ) along the somatodendritic axis
17 Yes Middle apical dendrite I p,q which is important for the induction of long term changes in synaptic strength"
18 Yes Middle apical dendrite I Na,t Single action potential backpropagations show dichotomy of either strong attenuation (26-42%) or weak attenuation (71-87%). The dichotomy seems to be conferred primarily by differences in distribution, density, etc. of voltage dependent sodium and potassium channel (A-type, especially ) along the somatodendritic axis
19 Yes Middle apical dendrite I T low threshold However, in a few apical patches the channel density was increased X 3, which could indicate channel clustering. Ca fluorescence imaging shows that application of T-channel antagonists reduces the Ca influx associated with backpropagating action potentials, and has a two-fold greater effect in the dendrites than in the soma
20 Yes Proximal apical dendrite I Na,t Single action potential backpropagations show dichotomy of either strong attenuation (26-42%) or weak attenuation (71-87%). The dichotomy seems to be conferred primarily by differences in distribution, density, etc. of voltage dependent sodium and potassium channel (A-type, especially ) along the somatodendritic axis
21 Yes Proximal apical dendrite I p,q which is important for the induction of long term changes in synaptic strength"
22 Yes Proximal apical dendrite I T low threshold However, in a few apical patches the channel density was increased X 3, which could indicate channel clustering. Ca fluorescence imaging shows that application of T-channel antagonists reduces the Ca influx associated with backpropagating action potentials, and has a two-fold greater effect in the dendrites than in the soma
23 Yes Proximal apical dendrite I L high threshold Ca fluorescence imaging shows that application of L-channel antagonists reduces the Ca influx associated with backpropagating action potentials, and has a significantly greater effect in the proximal dendrites than in more distal dendrites
24 Yes Middle basal dendrite I Na,t
25 Yes Proximal basal dendrite I Na,t
26 Yes Axon hillock I Na,t
27 Yes Axon fiber I Na,t
28 Yes Axon terminal I N
29 Yes Soma I M It was decreased by cannabinoids
30 Yes Distal apical dendrite I L high threshold Ca fluorescence imaging shows that application of L-channel antagonists reduces the Ca influx associated with backpropagating action potentials, and has a significantly greater effect in the proximal dendrites than in more distal dendrites
31 Yes Middle apical dendrite I L high threshold Ca fluorescence imaging shows that application of L-channel antagonists reduces the Ca influx associated with backpropagating action potentials, and has a significantly greater effect in the proximal dendrites than in more distal dendrites
32 Yes Distal apical dendrite I N Using confocal microscopy, these channels were found to be localized on the soma, dendrites, and a subpopulation of dendritic spines
33 Yes Middle apical dendrite Using confocal microscopy, these channels were found to be localized on the soma, dendrites, and a subpopulation of dendritic spines
34 Yes Middle apical dendrite I N Using confocal microscopy, these channels were found to be localized on the soma, dendrites, and a subpopulation of dendritic spines
35 Yes Middle apical dendrite I h Membrane patches recorded in the cell-attached patch configuration from the soma and apical dendrites revealed an Ih that increased over sixfold from soma to distal dendrites. Ih demonstrated a mixed Na+-K+ conductance and was sensitive to low concentrations of external CsCl. As a result of Ih the propagation of subthreshold voltage transients is directionally specific.The elevated dendritic Ih density decreases EPSP amplitude and duration and reduces the time window over which temporal summation takes place
36 Yes Proximal apical dendrite I h Membrane patches recorded in the cell-attached patch configuration from the soma and apical dendrites revealed an Ih that increased over sixfold from soma to distal dendrites. Ih demonstrated a mixed Na+-K+ conductance and was sensitive to low concentrations of external CsCl. As a result of Ih the propagation of subthreshold voltage transients is directionally specific.The elevated dendritic Ih density decreases EPSP amplitude and duration and reduces the time window over which temporal summation takes place
37 Yes Distal apical dendrite I h Membrane patches recorded in the cell-attached patch configuration from the soma and apical dendrites revealed an Ih that increased over sixfold from soma to distal dendrites. Ih demonstrated a mixed Na+-K+ conductance and was sensitive to low concentrations of external CsCl. As a result of Ih the propagation of subthreshold voltage transients is directionally specific.The elevated dendritic Ih density decreases EPSP amplitude and duration and reduces the time window over which temporal summation takes place
38 Yes Soma I h Membrane patches recorded in the cell-attached patch configuration from the soma and apical dendrites revealed an Ih that increased over sixfold from soma to distal dendrites. Ih demonstrated a mixed Na+-K+ conductance and was sensitive to low concentrations of external CsCl. As a result of Ih the propagation of subthreshold voltage transients is directionally specific.The elevated dendritic Ih density decreases EPSP amplitude and duration and reduces the time window over which temporal summation takes place
39 Yes Distal basal dendrite I K,Ca Amputation of the apical dendrite approximately 30 micron from the soma, while simultaneously recording the slow AHP whole cell current at the soma, depressed the sAHP amplitude by only approximately 30% compared with control. Somatic cell-attached and nucleated patches did not contain sAHP current. Amputation of the axon about 20um from the soma had little effect on the amplitude of the sAHP. By this process of elimination, it is suggested that sAHP channels may be concentrated in the basal dendrites of CA1 pyramids
40 Yes Soma I K,Ca The role of large-conductance Ca2+-dependent K+ channels (BK) in spike broadening during repetitive firing was studied using sharp electrode and computer modelling. The amplitude of the fast after-hyperpolarization (fAHP) rapidly declined during each train. Suppression of BK-channel activity with the selective BK-channel blocker iberiotoxin, the non-peptidergic BK-channel blocker paxilline, or calcium-free medium, broadened the 1st spike to a similar degree ( approximately 60 %)
41 Yes Proximal apical dendrite I A CA1 neurons and subiculum neurons in hippoampus differ in firing pattern (the former being regular and the later being either regular, weakly bursting or strongly bursting) and resting membrane properties (such as input restistance and membran time constant); however, low concentration of 4-AP (50 µM) can convert neurons in both regions into firing bursting action potentials
42 Yes Middle oblique dendrite I A Individual branches can function as single integrative compartments where the fast oblique spike contains contributions from NMDA, VGCCs, and the A current
43 Yes Proximal apical dendrite I Na,p Whole-cell somatic recording during TTX application to proximal dendrites suggests the presence of a persistent Na current
44 Yes Proximal apical dendrite I N Using confocal microscopy, these channels were found to be localized on the soma, dendrites, and a subpopulation of dendritic spines
 Neuronal Transmitters (2)
  
SN Property present CF-Compartment transmitter Connect Note Publication facts
1 Yes Axon terminal Glutamate Subiculum pyramidal neuron
2 Yes Proximal apical dendrite NO Experimental findings support a cascade for induction of homosynaptic, NO-dependent LTD involving activation of guanylyl cyclase, production of guanosine 3',5' cyclic monophosphate and subsequent PKG activation. This process has an additional requirement for release of Ca2+ from ryanodine-sensitive stores
Other categories referring to Hippocampus CA1 pyramidal GLU cell
Computational model.Model Neurons   (144)
Interneurons Connectivity.Principal Neurons   (1)
Pathological mechanism.Neuron   (13)
2 Objects Relationship (edge).Object Two (target)   (2)
Neural compartmental extracell.Neuron   (7)
Neural compartmental intracell.Neuron   (2)
ABA Genes.Neuron   (1)
Cell Type.NeuronDB Neuron   (1)
Neuronal Structure.Neurons   (1)
ICG channel details.ICG ModelDB cell   (5)
Pathological Interaction.Cell   (2)
Revisions: 17
Last Time: 12/18/2015 11:11:51 AM
Reviewer: System Administrator
Owner: System Administrator