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Resurgent Na+ current offers noise modulation in bursting neurons (Venugopal et al 2019)
Sharmila Venugopal
MesVModel [4438]
"Neurons utilize bursts of action potentials as an efficient and reliable way to encode information. It is likely that the intrinsic membrane properties of neurons involved in burst generation may also participate in preserving its temporal features. Here we examined the contribution of the persistent and resurgent components of voltage-gated Na+ currents in modulating the burst discharge in sensory neurons. Using mathematical modeling, theory and dynamic-clamp electrophysiology, we show that, distinct from the persistent Na+ component which is important for membrane resonance and burst generation, the resurgent Na+ can help stabilize burst timing features including the duration and intervals. ..."
  • Neuron or other electrically excitable cell Show Other
  • Venugopal S, Seki S, Terman DH, Pantazis A, Olcese R, Wiedau-Pazos M, Chandler SH (2019) Show Other
  • Venugopal, Sharmila [vsharmila at g.ucla.edu] Show Other
vsharmila@g.ucla.edu
S Venugopal*, S Seki, DH Terman, A Pantazis, R Olcese, M Wiedau-Pazos, SH Chandler, “Resurgent Na+ current offers noise modulation in bursting neurons”, PLoS Computational Biology, June 2019, 15(6): e1007154. doi: 10.1371/journal.pcbi.1007154.
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Revisions: 7
Last Time: 7/29/2019 5:33:14 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin