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Data
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LCN-HippoModel: model of CA1 PCs deep-superficial theta firing dynamics (Navas-Olive et al 2020)
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Andrea Navas-Olive
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Using a biophysically realistic model of CA1 pyramidal cells together with a combination of single-cell and multisite electrophysiological recordings, we have studied factors underlying the internal theta phase preference of identified cell types from the dorsal CA1.
We found that perisomatic inhibition delivered by complementary populations of basket cells interacts with input pathways to shape phase-locked specificity of deep and superficial CA1 pyramidal cells. Somatodendritic integration of fluctuating glutamatergic inputs defined cycle-by-cycle by nested waveforms demonstrated that firing selection is tuneable across sublayers under the relevant influence of intrinsic factors. Our data identify a set of testable physiological mechanisms underlying a phase specific firing reservoir that can be repurposed for high-level flexible dynamical representations. Documentation in https://acnavasolive.github.io/LCN-HippoModel/. More info: http://hippo-circuitlab.es/
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Hippocampus CA1 pyramidal GLU cell Show
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Neuron or other electrically excitable cell Show
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Navas-Olive A, Valero M, Jurado-Parras T, de Salas-Quiroga A, Averkin RG, Gambino G, Cid E, de la Prida LM (2020) Show
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Navas-Olive, Andrea [acnavasolive at gmail.com] Show
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acnavasolive@gmail.com
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I AHPs, I C, I Ca L, iCa T, I KDR
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Andrea Navas-Olive
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