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Data
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Single compartment: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
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Jan M Schulz
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This study shows that IPSCs mediated by a5-subunit containing GABAA receptors are strongly outward-rectifying generating 4-fold larger conductances above -50?mV than at rest. This model shows that synaptic activation of these receptors can very effectively control voltage-dependent NMDA-receptor activation.
The files contain the NEURON code for Fig.6 and Fig.7. The model is a single dendritic compartment with one glutamatergic and GABAergic synapse. Physiological properties of GABA synapses were modeled as determined by optogenetic activation of inputs during voltage-clamp recordings in Schulz et al. 2018.
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Schulz JM, Knoflach F, Hernandez MC, Bischofberger J (2018) Show
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Schulz, Jan M [j.schulz at unibas.ch] Show
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j.schulz@unibas.ch
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Schulz JM, Knoflach F, Hernandez MC, Bischofberger J.
Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear a5-GABAA receptors.
Nat Commun. 2018 Sep 3;9(1):3576. doi: 10.1038/s41467-018-06004-8.
PMID: 30177704
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