Computational model
Distinct integration properties of noisy inputs in active dendritic subunits (Poleg-Polsky 2019)
Alon Poleg-Polsky
sim_noise [321938]
The brain operates surprisingly well despite the noisy nature of individual neurons. The central mechanism for noise mitigation in the nervous system is thought to involve averaging over multiple noise-corrupted inputs. Subsequently, there has been considerable interest recently to identify noise structures that can be integrated linearly in a way that preserves reliable signal encoding. By analyzing realistic synaptic integration in biophysically accurate neuronal models, I report a complementary de-noising approach that is mediated by focal dendritic spikes. Dendritic spikes might seem to be unlikely candidates for noise reduction due to their miniscule integration compartments and poor averaging abilities. Nonetheless, the extra thresholding step introduced by dendritic spike generation increases neuronal tolerance for a broad category of noise structures, some of which cannot be resolved well with averaging. This property of active dendrites compensates for compartment size constraints and expands the repertoire of conditions that can be processed by neuronal populations.
  • Neocortex L2/3 pyramidal GLU cell Show Other
  • Neocortex primary motor area pyramidal layer 5 corticospinal cell Show Other
  • Polsky, Alon [alonpol at] Show Other
Neocortex layer 2-3 pyramidal
Poleg-Polsky, Alon
Other categories referring to Distinct integration properties of noisy inputs in active dendritic subunits (Poleg-Polsky 2019)
Revisions: 5
Last Time: 10/10/2019 5:20:49 PM
Reviewer: System Administrator
Owner: Tom Morse - MoldelDB admin