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Neostriatum medium spiny direct pathway GABA cell
117
 Neuronal Receptors (10)
  
SN Property present CF-Compartment Receptor Connect Note Publication facts
1 Yes Distal equivalent dendrite Glutamate Neocortical Superficial Pyramidal Neuron terminals (T) and Thalamic Relay Neuron terminals (T) From cerebral cortex
2 Yes Distal equivalent dendrite D1 Substantia Nigra Dopaminergic Cell terminals (T) Input from dopaminergic neurons in the substantia nigra; causes small depolarization? sometimes a decrease in firing rate; modulates anomalous rectification of dendritic membrane (I IR)?
3 Yes Middle equivalent dendrite Glutamate Neocortical Superficial Pyramidal Neuron terminals (T) and Thalamic Relay Neuron terminals (T) From cerebral cortex
4 Yes Middle equivalent dendrite D1 Substantia Nigra Dopaminergic Cell terminals (T) Input from dopaminergic neurons in the substantia nigra; causes small depolarization? sometimes a decrease in firing rate; modulates anomalous rectification of dendritic membrane (I IR)?
5 Yes Proximal equivalent dendrite Glutamate Neocortical Superficial Pyramidal Neuron terminals (T) and Thalamic Relay Neuron terminals (T) From cerebral cortex
6 Yes Proximal equivalent dendrite D1 Substantia Nigra Dopaminergic Cell terminals (T) Input from dopaminergic neurons in the substantia nigra; causes small depolarization? sometimes a decrease in firing rate; modulates anomalous rectification of dendritic membrane (I IR)?
7 Yes Soma D1 Recordings in slices showed that D1 receptor activation can either inhibit or enhance evoked activity, depending on the level of membrane depolarization, by modulating an L-type Ca2+ conductance
8 Yes Soma D2 Activation of both D1- and D2-class receptors has been shown to modulate potassium and sodium currents in acutely isolated neostriatal neurons
9 Yes Soma Gaba GABAergic responses evoked by electrical stimulations have been studied in slices
10 Yes Soma Muscarinic Recording from dissociated neurons using intracellular and whole-cell voltage-clamp recordings showed that carbachol can act at M1-like muscarinic receptors to reduce the membrane K+ conductances and excite the neostriatal neurons
 Neuronal Currents (20)
  
SN Property present CF-Compartment Current Connect Note Publication facts
1 Yes Soma I K
2 Yes Soma I Na,t Kinetic properties were studied using the whole-cell patch-clamp technique
3 Yes Distal equivalent dendrite I h Large EPSPs activate I IR, increasing the membrane resistance, shortening the dendrites electrotonically, making the cell more sensitive to subsequent inputs (see
4 Yes Middle equivalent dendrite I h Large EPSPs activate I IR, increasing the membrane resistance, shortening the dendrites electrotonically, making the cell more sensitive to subsequent inputs (see
5 Yes Proximal equivalent dendrite I h Large EPSPs activate I IR, increasing the membrane resistance, shortening the dendrites electrotonically, making the cell more sensitive to subsequent inputs (see
6 Yes Axon hillock I K
7 Yes Axon hillock I Na,t
8 Yes Axon terminal I N
9 Yes I L high threshold
10 Yes Soma I L high threshold However, recordings in slices showed that D1 receptor activation can either inhibit or enhance evoked activity, depending on the level of membrane depolarization, by modulating an L-type Ca2+ conductance
11 Yes Soma I N Whole-cell voltage-clamp recordings showed that HVA currents were present in at least 95% of neostriatal neurons, but that the majority of them appeared to belong neither to the "L-type" nor the "N-type" classification
12 Yes Soma I T low threshold Another study suggested that adult neostriatal projection neurons do not express significant levels of LVA Ca2+ current
13 Yes Soma I A A slowly inactivating A current has also been studied
14 Yes Soma I h The contribution of an inwardly rectifying current (IKir) were studied in slices. The results suggest that the hyperpolarized state is determined principally by this current
15 Yes Soma I Potassium A non-inactivating, Ca-independent, K+ current may limit the amplitude of membrane depolarizations associated with prolonged excursions into the depolarized state
16 Yes Soma I Calcium Whole cell recordings from acutely dissociated neurons exhibited a R-type currents that were characterized as HVA by their rapid deactivation kinetics, half-activation and half-inactivation voltages, and sensitivity to depolarized holding potentials. In neocortical pyramidal neurons these currents inactivated at more negative potentials than in medium spiny neurons
17 Yes Soma I K,Ca Calcium-dependent potassium channels are preferentially activated by calcium entry through N- and Q-type channels
18 Yes Soma I N Calcium-dependent potassium channels are preferentially activated by calcium entry through N- and Q-type channels
19 Yes Soma I p,q Calcium-dependent potassium channels are preferentially activated by calcium entry through N- and Q-type channels
20 Yes Soma I Na,p Nomarski optics and infrared videomicroscopy were used to demonstrate the existence of a TTX-sensitive persistent Na+ conductance (INaP) in identified medium-sized neostriatal neurons
 Neuronal Transmitters (1)
  
SN Property present CF-Compartment transmitter Connect Note Publication facts
1 Yes Axon terminal Gaba Indirect spiny neurons, globus pallidus external neuron, globus pallidus internal neuron, substantia nigra reticulata neurons
Other categories referring to Neostriatum medium spiny direct pathway GABA cell
Computational model.Model Neurons   (33)
Interneurons Connectivity.Principal Neurons   (1)
2 Objects Relationship (edge).Object Two (target)   (1)
Neuronal Structure.Neurons   (1)
ICG channel details.ICG ModelDB cell   (4)
Revisions: 11
Last Time: 11/1/2018 10:18:37 AM
Reviewer: System Administrator
Owner: System Administrator