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Multiscale model of primary motor cortex circuits predicts in vivo dynamics (Dura-Bernal et al 2023)
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Salvador Dura-Bernal
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Understanding cortical function requires studying multiple scales: molecular, cellular, circuit and behavior. We developed a multiscale biophysically-detailed model of mouse primary motor cortex (M1) with over 10,000 neurons and 30 million synapses. Neuron types, densities, spatial distributions, morphologies, biophysics, connectivity and dendritic synapse locations were constrained by experimental data. The model includes long-range inputs from seven thalamic and cortical regions, and noradrenergic inputs. Connectivity depends on cell class and cortical depth at sublaminar resolution. The model accurately predicted in vivo layer- and cell type-specific responses (firing rates and LFP) associated with behavioral states (quiet wakefulness and movement) and experimental manipulations (noradrenaline receptor blockade and thalamus inactivation). We generated mechanistic hypotheses underlying the observed activity and analyzed low-dimensional population latent dynamics. This quantitative theoretical framework can be used to integrate and interpret M1 experimental data and sheds light on the cell type-specific multiscale dynamics associated with several experimental conditions and behaviors.
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Neocortex L2/3 pyramidal GLU cell Show
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Neocortex M1 interneuron basket PV GABA cell Show
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Neocortex M1 interneuron chandelier SOM GABA cell Show
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Neocortex M1 L2/6 pyramidal intratelencephalic GLU cell Show
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Neocortex M1 L5B pyramidal pyramidal tract GLU cell Show
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Neocortex M1 L6 pyramidal corticothalamic GLU cell Show
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Neocortex L5/6 pyramidal GLU cell Show
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Hodgkin-Huxley neuron Show
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Neocortex primary motor area pyramidal layer 5 corticospinal cell Show
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Neocortex layer 2-3 interneuron Show
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Neocortex layer 5 interneuron Show
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Dura-Bernal S, Neymotin SA, Suter BA, Dacre J, Schiemann J, Duguid I, Shepherd GMG, Lytton WW (accepted) Show
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Dura-Bernal, Salvador [salvadordura at gmail.com] Show
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salvadordura@gmail.com
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Dura-Bernal S, Neymotin SA, Suter BA, Shepherd GMG, Lytton WW (2018) Long-range inputs and H-current regulate different modes of operation in a multiscale model of mouse M1 microcircuits. bioRxiv, 201707 [Preprint]
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