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Tonic activation of extrasynaptic NMDA-R promotes bistability (Gall & Dupont 2020)
David Gall
Our theoretical model provides a simple description of neuronal electrical activity that takes into account the tonic activity of extrasynaptic NMDA receptors and a cytosolic calcium compartment. We show that calcium influx mediated by the tonic activity of NMDA-R can be coupled directly to the activation of calcium-activated potassium channels, resulting in an overall inhibitory effect on neuronal excitability. Furthermore, the presence of tonic NMDA-R activity promotes bistability in electrical activity by dramatically increasing the stimulus interval where both a stable steady state and repetitive firing can coexist. These results could provide an intrinsic mechanism for the constitution of memory traces in neuronal circuits.
  • Cerebellum interneuron granule GLU cell Show Other
  • Neuron or other electrically excitable cell Show Other
GallDupont2019
dgall@ulb.ac.be
David Gall & Geneviève Dupont
Int J Mol Sci. 2019 Dec 27;21(1). pii: E206
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Revisions: 8
Last Time: 2/5/2020 4:11:43 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin