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Data
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Cortical Basal Ganglia Network Model during Closed-loop DBS (Fleming et al 2020)
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John E. Fleming
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We developed a computational model of the cortical basal ganglia network to investigate closed-loop control of deep brain stimulation (DBS) for Parkinson’s disease (PD). The cortical basal ganglia network model incorporates the (i) the extracellular DBS electric field, (ii) antidromic and orthodromic activation of STN afferent fibers, (iii) the LFP detected at non-stimulating contacts on the DBS electrode and (iv) temporal variation of network beta-band activity within the thalamo-cortico-basal ganglia loop. The model facilitates investigation of clinically-viable closed-loop DBS control approaches, modulating either DBS amplitude or frequency, using an LFP derived measure of network beta-activity.
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Fleming JE, Dunn E, Lowery MM (2020) Show
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John E. Fleming, John E [john.fleming at ucdconnect.ie] Show
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john.fleming@ucdconnect.ie
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Beta Burst Durations
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John E. Fleming
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