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A gap junction network of Amacrine Cells controls Nitric Oxide release (Jacoby et al 2018)
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Tom Morse - MoldelDB admin
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"... The effects of the neuromodulator nitric oxide (NO) have
been studied in many circuits, including in the vertebrate
retina, where it regulates synaptic release, gap junction
coupling, and blood vessel dilation, but little is known about
the cells that release NO. We show that a single type of amacrine
cell (AC) controls NO release in the inner retina, and we report
its light responses, electrical properties, and calcium
dynamics. We discover that this AC forms a dense gap junction
network and that the strength of electrical coupling in the
network is regulated by light through NO. A model of the network
offers insights into the biophysical specializations leading to
auto-regulation of NO release within the network."
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Jacoby J, Nath A, Jessen ZF, Schwartz GW (2018) Show
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Jessen, Zachary F Show
Other
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Schwartz, Gregory W [greg.schwartz at northwestern.edu] Show
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tom.morse@yale.edu
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A Self-Regulating Gap Junction Network of Amacrine Cells Controls Nitric Oxide Release in the Retina.
Jacoby J1, Nath A2, Jessen ZF3, Schwartz GW4.
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