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Complex dynamics: reproducing Golgi cell electroresponsiveness (Geminiani et al 2018, 2019ab)
Pipeline user 82
Excerpts from three papers abstracts: "Brain neurons exhibit complex electroresponsive properties – including intrinsic subthreshold oscillations and pacemaking, resonance and phase-reset – which are thought to play a critical role in controlling neural network dynamics. Although these properties emerge from detailed representations of molecular-level mechanisms in “realistic” models, they cannot usually be generated by simplified neuronal models (although these may show spike-frequency adaptation and bursting). We report here that this whole set of properties can be generated by the extended generalized leaky integrate-and-fire (E-GLIF) neuron model. ..." "... In order to reproduce these properties in single-point neuron models, we have optimized the Extended-Generalized Leaky Integrate and Fire (E-GLIF) neuron through a multi-objective gradient-based algorithm targeting the desired input–output relationships. ..." " ... In order to investigate how single neuron dynamics and geometrical modular connectivity affect cerebellar processing, we have built an olivocerebellar Spiking Neural Network (SNN) based on a novel simplification algorithm for single point models (Extended Generalized Leaky Integrate and Fire, EGLIF) capturing essential non-linear neuronal dynamics (e.g., pacemaking, bursting, adaptation, oscillation and resonance). ..."
  • Abstract integrate-and-fire leaky neuron Show Other
  • Geminiani A, Casellato C, Locatelli F, Prestori F, Pedrocchi A, D'Angelo E (2018) Show Other
  • Geminiani A, Casellato C, D'Angelo E, Pedrocchi A (2019) Show Other
  • Geminiani A, Pedrocchi A, D'Angelo E, Casellato C (2019) Show Other
  • Geminiani, Alice [alice.geminiani at unipv.it] Show Other
  • Casellato, Claudia [claudia.casellato at unipv.it] Show Other
tom.morse@yale.edu
Geminiani, Alice [alice.geminiani at unipv.it]Casellato, Claudia [claudia.casellato at unipv.it]
https://www.frontiersin.org/articles/10.3389/fninf.2018.00088/full
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Revisions: 14
Last Time: 4/1/2020 10:29:38 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Bulletin Board System