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Computational Modelling of TNFalpha Pathway in Parkinson's Disease (Sasidharakurup et al 2019)
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"The paper aims developing a computational framework of signaling using the principles of biochemical systems theory as a model for Parkinson’s disease. Several molecular interactions aided by TNFalpha, a proinflammatory cytokine play key roles in mediating glutamate excitotoxicity and neuroinflammation, resulting in neuronal cell death. In this paper, initial concentrations and rate constants were extracted from literature and simulations developed were based on systems of ordinary differential equations following first-order kinetics. In control or healthy conditions, a decrease in TNFalpha and neuronal cell death was predicted in simulations matching data from experiments, whereas in diseased condition, a drastic increase in levels of TNFalpha, glutamate, TNFR1 and ROS were observed similar to experimental data correlating diseased condition to augmented neuronal cell death. The study suggests toxic effects induced by TNFalpha in the substantia nigra may be attributed to Parkinson’s disease conditions."
  • Sasidharakurup H, Nair L, Bhaskar K, Diwakar S (2020) Show Other
  • Diwakar, Shyam [shyam at amrita.edu] Show Other
tom.morse@yale.edu
Systems Biology
Hemalatha Sasidharakurup (hemalathas@am.amrita.edu)
https://link.springer.com/chapter/10.1007/978-3-030-36683-4_61
False
False
Other categories referring to Computational Modelling of TNFalpha Pathway in Parkinson's Disease (Sasidharakurup et al 2019)
Revisions: 8
Last Time: 4/7/2020 10:29:04 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Bulletin Board System