Computational model
Levodopa-Induced Toxicity in Parkinson's Disease (Muddapu et al, 2022)
Vignayanandam R Muddapu
"... We present a systems-level computational model of SNc-striatum, which will help us understand the mechanism behind neurodegeneration postulated above and provide insights into developing disease-modifying therapeutics. It was observed that SNc terminals are more vulnerable to energy deficiency than SNc somas. During L-DOPA therapy, it was observed that higher L-DOPA dosage results in increased loss of terminals in SNc. It was also observed that co-administration of L-DOPA and glutathione (antioxidant) evades L-DOPA-induced toxicity in SNc neurons. Our proposed model of the SNc-striatum system is the first of its kind, where SNc neurons were modeled at a biophysical level, and striatal neurons were modeled at a spiking level. We show that our proposed model was able to capture L-DOPA-induced toxicity in SNc, caused by energy deficiency."
  • Substantia nigra pars compacta DA cell Show Other
  • Neostriatum medium spiny direct pathway GABA cell Show Other
  • Globus pallidus principal GABA cell Show Other
  • Muddapu VR, Vijayakumar K, Ramakrishnan K, Chakravarthy VS (2022) Show Other
  • Muddapu, Vignayanandam R. [vignan.0009 at] Show Other
  • Chakravarthy, Srinivasa V. [schakra at] Show Other
D1-R, D2-R, NK1-R
Substance P
Other categories referring to Levodopa-Induced Toxicity in Parkinson's Disease (Muddapu et al, 2022)
Revisions: 4
Last Time: 4/20/2022 12:21:32 PM
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