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Neocortex L5/6 pyramidal GLU cell
Cajal, S. Ramon y (1911). Reprinted and translated by Swanson and Swanson, Oxford University Press, 1995.
The cell bodies (somas) of these projection neurons are found in the (deeper) layers 5/6 of cortex, and have a pyramid shape. These cells release glutamate, the most common excitatory neurotransmitter. These are corticothalamic (project to the thalamus), pyramidal tract (project to the brain stem and spinal cord), and intratelencephalic (project to the cortex, possibly the other hemisphere, or the basal ganglia). Where the axon goes determines these additional classes. The apical tuft is thicker for the subtypes of these cells primarily in layer 5b (deeper layer 5) that project to subcortical regions and thinner for those in layer 5a (superficial layer 5) that project through the corpus callosum to the other hemisphere.
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 Neuronal Receptors (25)
  
SN Property present CF-Compartment Receptor Connect Note Publication facts
1 Yes Soma NMDA The rate of NMDAR channel opening was studied in response to depolarisations at different times after brief (1 ms) and sustained (4.6 s) applications of glutamate to nucleated patches from neocortical pyramidal neurons
2 Yes Distal apical dendrite NMDA Apical dendrites of L6 pyramidal neurons in somatosensory cortex are similar to L5 and L2/3 in that they includeNMDA-dependent electrogenesis
3 Yes Middle apical dendrite GabaB The distribution of GABAA and GABAB receptors was studied with patch-clamp recording in combination with infrared-guided laser stimulation to release GABA photolytically. The data suggest that relatively more GABAA receptors are located at the apical dendrite and relatively more GABAB receptors near the soma
4 Yes Distal apical dendrite GabaA The distribution of GABAA and GABAB receptors was studied with patch-clamp recording in combination with infrared-guided laser stimulation to release GABA photolytically. The data suggest that relatively more GABAA receptors are located at the apical dendrite and relatively more GABAB receptors near the soma
5 Yes Distal apical dendrite GabaB The distribution of GABAA and GABAB receptors was studied with patch-clamp recording in combination with infrared-guided laser stimulation to release GABA photolytically. The data suggest that relatively more GABAA receptors are located at the apical dendrite and relatively more GABAB receptors near the soma
6 Yes Axon terminal D1 Dual whole-cell recordings in connected cell pairs suggested that attenuation of local horizontal excitation by dopamine is through D1 actions at a presynaptic site
7 Yes Proximal apical dendrite GabaA The distribution of GABAA and GABAB receptors was studied with patch-clamp recording in combination with infrared-guided laser stimulation to release GABA photolytically. The data suggest that relatively more GABAA receptors are located at the apical dendrite and relatively more GABAB receptors near the soma
8 Yes Proximal apical dendrite GabaB The distribution of GABAA and GABAB receptors was studied with patch-clamp recording in combination with infrared-guided laser stimulation to release GABA photolytically. The data suggest that relatively more GABAA receptors are located at the apical dendrite and relatively more GABAB receptors near the soma
9 Yes Middle apical dendrite GabaA The distribution of GABAA and GABAB receptors was studied with patch-clamp recording in combination with infrared-guided laser stimulation to release GABA photolytically. The data suggest that relatively more GABAA receptors are located at the apical dendrite and relatively more GABAB receptors near the soma
10 Yes Distal apical dendrite 5-HT2 Immunolabeling was observed in soma and dendrites of layer V pyramidal cells in the frontal cortex
11 Yes Middle apical dendrite 5-HT2 Immunolabeling was observed in soma and dendrites of layer V pyramidal cells in the frontal cortex
12 Yes Proximal apical dendrite 5-HT2 Immunolabeling was observed in soma and dendrites of layer V pyramidal cells in the frontal cortex
13 Yes Soma 5-HT2 Immunolabeling was observed in soma and dendrites of layer V pyramidal cells in the frontal cortex
14 Yes Soma GabaA Basket Cell Interneuron terminals (T) The distribution of GABAA and GABAB receptors was studied with patch-clamp recording in combination with infrared-guided laser stimulation to release GABA photolytically. The data suggest that relatively more GABAA receptors are located at the apical dendrite and relatively more GABAB receptors near the soma
15 Yes Soma GabaB Basket Cell Interneuron terminals (T) The distribution of GABAA and GABAB receptors was studied with patch-clamp recording in combination with infrared-guided laser stimulation to release GABA photolytically. The data suggest that relatively more GABAA receptors are located at the apical dendrite and relatively more GABAB receptors near the soma
16 Yes Distal apical dendrite Glutamate ----- Recordings using infrared-guided laser stimulation combined with whole cell recordings revealed a highly nonuniform distribution. Hot spots, with amplitude and integral of glutamate-evoked responses three times larger than responses evoked at neighboring sites, were detected. It appeared that the larger responses evoked resulted from an increase in activation of both AMPA and NMDA receptors. There was no correlation with branch points
17 Yes Middle apical dendrite Glutamate ----- Recordings using infrared-guided laser stimulation combined with whole cell recordings revealed a highly nonuniform distribution. Hot spots, with amplitude and integral of glutamate-evoked responses three times larger than responses evoked at neighboring sites, were detected. It appeared that the larger responses evoked resulted from an increase in activation of both AMPA and NMDA receptors. There was no correlation with branch points
18 Yes Proximal apical dendrite Glutamate ----- Recordings using infrared-guided laser stimulation combined with whole cell recordings revealed a highly nonuniform distribution. Hot spots, with amplitude and integral of glutamate-evoked responses three times larger than responses evoked at neighboring sites, were detected. It appeared that the larger responses evoked resulted from an increase in activation of both AMPA and NMDA receptors. There was no correlation with branch points
19 Yes Distal basal dendrite Glutamate -----
20 Yes Middle basal dendrite Glutamate -----
21 Yes Proximal basal dendrite Glutamate -----
22 Yes Axon hillock GabaA Chandelier Cell Interneuron terminals (T)
23 Yes Axon hillock GabaB Chandelier Cell Interneuron terminals (T)
24 Yes GabaA
25 Yes GabaB
 Neuronal Currents (41)
  
SN Property present CF-Compartment Current Connect Note Publication facts
1 Yes Distal apical dendrite I K
2 Yes Distal apical dendrite I A
3 Yes Middle apical dendrite I K
4 Yes Middle apical dendrite I A
5 Yes Proximal apical dendrite I K
6 Yes Distal apical dendrite I Calcium Using calcium imaging, calcium waves in layer 2/3 and layer 5 neocortical somatosensory pyramidal neurons were examined in slices from 2- to 8-week-old rats
7 Yes Distal apical dendrite I h A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course
8 Yes Middle apical dendrite I h A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course
9 Yes Proximal apical dendrite I h A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course
10 Yes Soma I h A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course
11 Yes Distal basal dendrite I h The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance
12 Yes Middle basal dendrite I h The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance
13 Yes Proximal basal dendrite I h The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance
14 Yes Soma I A
15 Yes Proximal apical dendrite I A
16 Yes Soma I K,Ca Ca2+-activated K+ currents were studied using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons
17 Yes Middle apical dendrite I N Dendritic fluorescence imaging showed that Ca2+ channels of several subtypes mediated the AP-evoked fluorescence transient in the proximal (100-170 microns) apical dendrite. The fluorescence resulted from Ca2+ entry through L, N, and P-type channels, and through Ca2+ channels (R-type) not sensitive to L-, N- and P-type Ca2+ channel blockers
18 Yes Middle apical dendrite I L high threshold Dendritic fluorescence imaging showed that Ca2+ channels of several subtypes mediated the AP-evoked fluorescence transient in the proximal (100-170 microns) apical dendrite. The fluorescence resulted from Ca2+ entry through L, N, and P-type channels, and through Ca2+ channels (R-type) not sensitive to L-, N- and P-type Ca2+ channel blockers
19 Yes Middle apical dendrite I Calcium Using calcium imaging, calcium waves in layer 2/3 and layer 5 neocortical somatosensory pyramidal neurons were examined in slices from 2- to 8-week-old rats
20 Yes Proximal apical dendrite I Calcium Using calcium imaging, calcium waves in layer 2/3 and layer 5 neocortical somatosensory pyramidal neurons were examined in slices from 2- to 8-week-old rats
21 Yes Proximal apical dendrite I L high threshold Dendritic fluorescence imaging showed that Ca2+ channels of several subtypes mediated the AP-evoked fluorescence transient in the proximal (100-170 microns) apical dendrite. The fluorescence resulted from Ca2+ entry through L, N, and P-type channels, and through Ca2+ channels (R-type) not sensitive to L-, N- and P-type Ca2+ channel blockers
22 Yes Proximal apical dendrite I N Dendritic fluorescence imaging showed that Ca2+ channels of several subtypes mediated the AP-evoked fluorescence transient in the proximal (100-170 microns) apical dendrite. The fluorescence resulted from Ca2+ entry through L, N, and P-type channels, and through Ca2+ channels (R-type) not sensitive to L-, N- and P-type Ca2+ channel blockers
23 Yes Soma I Na,t
24 Yes Soma I K
25 Yes Soma I Na,p This persistant conductance may be activated by the NMDA receptor depolarization, providing a mechanism for graded, voltage dependent EPSP amplification
26 Yes Distal apical dendrite I p,q Many authors have described the activation of dendritic voltage activated Ca channels
27 Yes Distal apical dendrite I Na,t
28 Yes Middle apical dendrite I Na,p This persistant conductance may be activated by the NMDA receptor depolarization, providing a mechanism for graded, voltage dependent EPSP amplification
29 Yes Middle apical dendrite I Na,t
30 Yes Middle apical dendrite I p,q Many authors have described the activation of dendritic voltage activated Ca channels
31 Yes Proximal apical dendrite I Na,p This persistant conductance may be activated by the NMDA receptor depolarization, providing a mechanism for graded, voltage dependent EPSP amplification
32 Yes Proximal apical dendrite I Na,t
33 Yes Proximal apical dendrite I p,q Many authors have described the activation of dendritic voltage activated Ca channels
34 Yes Axon hillock I Na,t
35 Yes Axon hillock I K
36 Yes Axon fiber I Na,t
37 Yes Axon terminal I N
38 Yes Soma I CAN using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons showed that Ca2+-dependent K+ currents were activated by Ca2+ entry through both N- and L-type channels
39 Yes Soma I L high threshold using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons showed that Ca2+-dependent K+ currents were activated by Ca2+ entry through both N- and L-type channels
40 Yes Soma I Calcium Using calcium imaging, calcium waves in layer 2/3 and layer 5 neocortical somatosensory pyramidal neurons were examined in slices from 2- to 8-week-old rats
41 Yes Distal apical dendrite I Na,p This persistant conductance may be activated by the NMDA receptor depolarization, providing a mechanism for graded, voltage dependent EPSP amplification
 Neuronal Transmitters (3)
  
SN Property present CF-Compartment transmitter Connect Note Publication facts
1 Yes Soma Glutamate Dual whole-cell recordings in acute slices showed that kainate receptors located on presynaptic interneuron terminals can be activated by glutamate released from the somatodendritic compartment of the postsynaptic pyramidal cells
2 Yes Proximal apical dendrite Glutamate Dual whole-cell recordings in acute slices showed that kainate receptors located on presynaptic interneuron terminals can be activated by glutamate released from the somatodendritic compartment of the postsynaptic pyramidal cells
3 Yes Axon terminal Glutamate Spiny Neuron: Ded and Thalamic Relay Neuron: Ded and Superficial Pyramidal Neurons From cerebral cortex
Other categories referring to Neocortex L5/6 pyramidal GLU cell
Computational model.Model Neurons   (122)
Interneurons Connectivity.Principal Neurons   (1)
Pathological mechanism.Neuron   (2)
2 Objects Relationship (edge).Object Two (target)   (1)
Neural compartmental intracell.Neuron   (1)
Cell Type.NeuronDB Neuron   (1)
Neuronal Structure.Neurons   (1)
Revisions: 18
Last Time: 10/10/2019 5:13:16 PM
Reviewer: System Administrator
Owner: System Administrator