Computational model
Hippocampus CA1 Interneuron Specific 3 (IS3) in vivo-like virtual NN simulations (Luo et al 2020)
Pipeline user 82
LuoEtAl2020Code [1300127]
"Disinhibition is a widespread circuit mechanism for information selection and transfer. In the hippocampus, disinhibition of principal cells is provided by the interneuron-specific interneurons that express the vasoactive intestinal polypeptide (VIP-IS) and innervate selectively inhibitory interneurons. By combining optophysiological experiments with computational models, we determined the impact of synaptic inputs onto the network state-dependent recruitment of VIP-IS cells. We found that VIP-IS cells fire spikes in response to both the Schaffer collateral and the temporoammonic pathway activation. Moreover, by integrating their intrinsic and synaptic properties into computational models, we predicted recruitment of these cells between the rising phase and peak of theta oscillation and during ripples. Two-photon Ca2+-imaging in awake mice supported in part the theoretical predictions, revealing a significant speed modulation of VIP-IS cells and their preferential albeit delayed recruitment during theta-run epochs, with estimated firing at the rising phase and peak of the theta cycle. However, it also uncovered that VIP-IS cells are not activated during ripples. Thus, given the preferential theta-modulated firing of VIP-IS cells in awake hippocampus, we postulate that these cells may be important for information gating during spatial navigation and memory encoding."
  • Luo X, Guet-McCreight A, Villette V, Francavilla R, Marino B, Chamberland S, Skinner FK, Topolnik L (2020) Show Other
  • Guet-McCreight, Alexandre [alexandre.guet.mccreight at] Show Other
Interneuron Specific 3
I Kdrf
Other categories referring to Hippocampus CA1 Interneuron Specific 3 (IS3) in vivo-like virtual NN simulations (Luo et al 2020)
Revisions: 8
Last Time: 5/7/2020 6:00:08 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Bulletin Board System