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Data
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The microcircuits of striatum in silico (Hjorth et al 2020)
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Tom Morse - MoldelDB admin
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"Our aim is to reconstruct a full-scale mouse striatal cellular level model to provide a framework to integrate and interpret striatal data. We represent the main striatal neuronal subtypes, the two types of projection neurons (dSPNs and iSPNs) giving rise to the direct and indirect pathways, the fast-spiking interneurons, the low threshold spiking interneurons, and the cholinergic interneurons as detailed compartmental models, with properties close to their biological counterparts. Both intrastriatal and afferent synaptic inputs (cortex, thalamus, dopamine system) are optimized against existing data, including short-term plasticity. This model platform will be used to generate new hypotheses on striatal function or network dynamic phenomena."
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Neostriatum medium spiny direct pathway GABA cell Show
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Neostriatum medium spiny indirect pathway GABA cell Show
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Neostriatum interneuron ACh cell Show
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Neostriatum interneuron gaba/parvalbumin GABA cell Show
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Neostriatum interneuron SOM/NOS GABA cell Show
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Hjorth JJJ, Kozlov A, Carannante I, Frost Nylén J, Lindroos R, Johansson Y, Tokarska A, Dorst MC, Suryanarayana SM, Silberberg G, Hellgren Kotaleski J, Grillner S (2020) Show
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Hjorth, Johannes [hjorth at csc.kth.se] Show
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tom.morse@yale.edu
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