|
|
|
Data
|
Cerebellar granule cell (Masoli et al 2020)
|
Stefano Masoli
|
|
|
|
|
"The cerebellar granule cells (GrCs) are classically described as a homogeneous neuronal population discharging
regularly without adaptation. We show that GrCs in fact generate diverse response patterns to current injection
and synaptic activation, ranging from adaptation to acceleration of firing. Adaptation was predicted by parameter
optimization in detailed computational models based on available knowledge on GrC ionic channels. The models also
predicted that acceleration required additional mechanisms. We found that yet unrecognized TRPM4 currents specifically
accounted for firing acceleration and that adapting GrCs outperformed accelerating GrCs in transmitting high-frequency
mossy fiber (MF) bursts over a background discharge. This implied that GrC subtypes identified by their
electroresponsiveness corresponded to specific neurotransmitter release probability values. Simulations showed
that fine-tuning of pre- and post-synaptic parameters generated effective MF-GrC transmission channels, which
could enrich the processing of input spike patterns and enhance spatio-temporal recoding at the cerebellar input stage."
|
-
Cerebellum interneuron granule GLU cell Show
Other
|
|
|
|
|
|
|
-
Neuron or other electrically excitable cell Show
Other
|
|
|
|
|
-
Masoli S, Tognolina M, Laforenza U, Moccia F, D'Angelo E (2020) Show
Other
|
|
|
265584
|
|
|
|
|
|
|
-
Masoli, Stefano [stefano.masoli at unipv.it] Show
Other
|
stefano.masoli@unipv.it
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
