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Neocortex L2/3 pyramidal GLU cell
Cajal, S. Ramon y (1911). Reprinted and translated by Swanson and Swanson, Oxford University Press, 1995.
The cell bodies (somas) of these projection neurons are in the (superficial) layers 2/3 of cortex, and have a pyramid shape. These cells release glutamate, the most common excitatory neurotransmitter. These are intratelencephalic (project to the cortex, possibly the other hemisphere, or the basal ganglia) however intratelencephalic cells can also have their cell bodies in deeper cortical layers.
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 Neuronal Receptors (16)
  
SN Property present CF-Compartment Receptor Connect Note Publication facts
1 Yes Middle apical dendrite NMDA
2 Yes Proximal apical dendrite NMDA
3 Yes Soma GabaB Basket Cell Interneuron terminals (T)
4 Yes Soma GabaA Basket Cell Interneuron terminals (T) GABA from basket cell inhibitory interneurons.
5 Yes Distal apical dendrite Glutamate Deep pyramidal neuron terminals (T) from other regions; some TC terminals (T)
6 Yes Middle apical dendrite Glutamate Deep pyramidal neuron terminals (T) from other regions; some TC terminals (T)
7 Yes Proximal apical dendrite Glutamate Deep pyramidal neuron terminals (T) from other regions; some TC terminals (T)
8 Yes Distal basal dendrite Glutamate TC terminals (T)
9 Yes Middle basal dendrite Glutamate TC terminals (T)
10 Yes Proximal basal dendrite Glutamate TC terminals (T)
11 Yes Axon hillock GabaB Chandelier Cell Interneuron terminals (T)
12 Yes Axon hillock GabaA Chandelier Cell Interneuron terminals (T) GABA from chandelier inhibitory interneurons.
13 Yes Distal apical dendrite GabaA
14 Yes Distal apical dendrite NMDA
15 Yes Soma AMPA Simultaneous recordings were carried out in visual cortical slices. Assuming open probability of non-NMDA receptor channels to be 0.7, it is suggested that the number of channels available for synaptic transmission between individual pyramidal cells would be 74 (kittens) and 59 (rats)
16 Yes Distal apical dendrite mGluR
 Neuronal Currents (20)
  
SN Property present CF-Compartment Current Connect Note Publication facts
1 Yes Proximal apical dendrite I Calcium Using calcium imaging, calcium waves in layer 2/3 and layer 5 neocortical somatosensory pyramidal neurons were examined in slices from 2- to 8-week-old rats
2 Yes Distal apical dendrite I Calcium Using calcium imaging, calcium waves in layer 2/3 and layer 5 neocortical somatosensory pyramidal neurons were examined in slices from 2- to 8-week-old rats
3 Yes Soma I Na,t Recordings from acute brain slices and in anesthetized rats using whole-cell recordings and Ca2+ imaging found that backpropagation of action potentials into the dendritic arbor is actively supported by Na+ channels both in vitro and in vivo.
4 Yes Distal apical dendrite I p,q
5 Yes Distal apical dendrite I Na,t Recordings from acute brain slices and in anesthetized rats using whole-cell recordings and Ca2+ imaging found that backpropagation of action potentials into the dendritic arbor is actively supported by Na+ channels both in vitro and in vivo.
6 Yes Middle apical dendrite I p,q
7 Yes Middle apical dendrite I Na,t Recordings from acute brain slices and in anesthetized rats using whole-cell recordings and Ca2+ imaging found that backpropagation of action potentials into the dendritic arbor is actively supported by Na+ channels both in vitro and in vivo.
8 Yes Proximal apical dendrite I Na,t Recordings from acute brain slices and in anesthetized rats using whole-cell recordings and Ca2+ imaging found that backpropagation of action potentials into the dendritic arbor is actively supported by Na+ channels both in vitro and in vivo.
9 Yes Proximal apical dendrite I p,q
10 Yes Axon hillock I Na,t
11 Yes Axon hillock I K
12 Yes Axon fiber I Na,t
13 Yes Axon terminal I N
14 Yes Distal basal dendrite I Calcium Action potential-evoked Ca2+ signals in spines of basal dendrites decreased slightly with distance from the soma
15 Yes Middle basal dendrite I Calcium Action potential-evoked Ca2+ signals in spines of basal dendrites decreased slightly with distance from the soma
16 Yes Proximal basal dendrite I Calcium Action potential-evoked Ca2+ signals in spines of basal dendrites decreased slightly with distance from the soma
17 Yes Soma I K,Ca Ca2+-activated K+ currents were studied using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons
18 Yes Middle apical dendrite I Calcium Using calcium imaging, calcium waves in layer 2/3 and layer 5 neocortical somatosensory pyramidal neurons were examined in slices from 2- to 8-week-old rats
19 Yes Soma I Calcium Using calcium imaging, calcium waves in layer 2/3 and layer 5 neocortical somatosensory pyramidal neurons were examined in slices from 2- to 8-week-old rats
20 Yes Soma I L high threshold using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons showed that Ca2+-dependent K+ currents were activated by Ca2+ entry through both N- and L-type channels
 Neuronal Transmitters (4)
  
SN Property present CF-Compartment transmitter Connect Note Publication facts
1 Yes Axon terminal Glutamate Deep pyramidal neurons and interneurons
2 Yes Proximal apical dendrite Glutamate Dual whole-cell recordings showed that Ca2+-dependent release of a retrograde messenger, most probably glutamate, from dendrites suppresses the inhibition of pyramidal neurons
3 Yes Middle apical dendrite Glutamate Dual whole-cell recordings showed that Ca2+-dependent release of a retrograde messenger, most probably glutamate, from dendrites suppresses the inhibition of pyramidal neurons
4 Yes Distal apical dendrite Glutamate Dual whole-cell recordings showed that Ca2+-dependent release of a retrograde messenger, most probably glutamate, from dendrites suppresses the inhibition of pyramidal neurons
Other categories referring to Neocortex L2/3 pyramidal GLU cell
Computational model.Model Neurons   (77)
Interneurons Connectivity.Principal Neurons   (1)
2 Objects Relationship (edge).Object Two (target)   (1)
Neural compartmental intracell.Neuron   (1)
Neuronal Structure.Neurons   (1)
Revisions: 24
Last Time: 10/10/2019 5:13:40 PM
Reviewer: System Administrator
Owner: System Administrator