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Data
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Cholinergic and nicotinic regulation of DA neuron firing (Morozova et al 2020)
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Ekaterina O Morozova
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The model describes the modulation of firing properties of DA neurons by acetylcholine (ACh) and nicotine in 5 cases: knock-out of ß2-containing nAChRs, ß2-containing nAChRs only on DA neurons, the nAChRs only on GABA neurons, the nAChRs on both DA and GABA neurons and “wild” type (the AChRs on DA, GABA and Glu neurons). The distinct responses to ACh and nicotine could be explained by distinct temporal patterns of these inputs: pulsatile vs. continuous.
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Ventral tegmental area dopamine neuron Show
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Ventral tegmental area GABA neuron Show
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Neuron or other electrically excitable cell Show
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Morozova E, Faure P, Gutkin B, Lapish C, Kuznetsov A (2020) Show
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Morozova, Ekaterina O [emorozov at indiana.edu] Show
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morozova.e.o@gmail.com
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