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Cholinergic and nicotinic regulation of DA neuron firing (Morozova et al 2020)
Ekaterina O Morozova
The model describes the modulation of firing properties of DA neurons by acetylcholine (ACh) and nicotine in 5 cases: knock-out of ß2-containing nAChRs, ß2-containing nAChRs only on DA neurons, the nAChRs only on GABA neurons, the nAChRs on both DA and GABA neurons and “wild” type (the AChRs on DA, GABA and Glu neurons). The distinct responses to ACh and nicotine could be explained by distinct temporal patterns of these inputs: pulsatile vs. continuous.
  • Ventral tegmental area dopamine neuron Show Other
  • Ventral tegmental area GABA neuron Show Other
  • Neuron or other electrically excitable cell Show Other
  • Morozova E, Faure P, Gutkin B, Lapish C, Kuznetsov A (2020) Show Other
  • Morozova, Ekaterina O [emorozov at indiana.edu] Show Other
morozova.e.o@gmail.com
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Revisions: 7
Last Time: 5/21/2020 2:58:44 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin