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Interplay between somatic and dendritic inhibition promotes place fields (Pedrosa & Clopath 2020)
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Victor Pedrosa
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Hippocampal pyramidal neurons are thought to encode spatial information. A subset of these cells, named place cells, are active only when the animal traverses a specific region within the environment. Although vastly studied experimentally, the development and stabilization of place fields are not fully understood. Here, we propose a mechanistic model of place cell formation in the hippocampal CA1 region. Using our model, we reproduce place field dynamics observed experimentally and provide a mechanistic explanation for the stabilization of place fields. Finally, our model provides specific predictions on protocols to shift place field location.
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Pedrosa, Victor [v.pedrosa15 at imperial.ac.uk] Show
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v.pedrosa@imperial.ac.uk
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