Computational model
Ventral medial entorhinal cortical stellate neuron model: the role of T-type Ca2+ and persistent Na+
Michele Migliore
modelDB [130345]
Dorsal and ventral medial entorhinal cortex (mEC) regions have distinct neural network firing patterns to differentially support functions such as spatial memory. Correspondingly, mEC layer II stellate neuron action potential frequencies vary across the dorsal-ventral axis, with dorsal neurons exhibiting lower firing rates than ventral neurons. This has been partly attributed to higher densities of inhibitory conductances in dorsal compared to ventral neurons. We asked whether additional conductances might also impact this dorsal-ventral gradient in spike firing. We report that T-type Ca 2+ current amplitudes increased three-fold along the dorsal-ventral axis in mEC layer II stellate neurons. Twice as much Ca V 3.2 mRNA was also detected in ventral mEC compared with dorsal mEC. Unusually, as T-type Ca 2+ currents are only transiently active, long depolarizing stimuli applied to ventral, and not dorsal, stellate neurons triggered these currents to cause a sustained rise in membrane voltage and spike firing. This effect was due to T-type Ca 2+ currents acting in concert with persistent Na + currents. T-type Ca 2+ currents themselves prolonged excitatory post-synaptic potentials (EPSPs) to enhance the summation of EPSP trains and augment EPSP-spike coupling in ventral neurons. In contrast, T-type Ca 2+ currents had no effect on dorsal EPSP spike- coupling. These findings indicate that by preferentially regulating ventral neuron spike firing and synaptic potential integration, T-type Ca 2+ currents critically influence the dorsal-ventral gradient in mEC stellate neuron excitability and associated circuit activity.
  • Topczewska A, Giacalone E, Pratt WS, Migliore M, Dolphin AC, Shah MM (2023) Show Other
  • Giacalone, Elisabetta [elisabetta.giacalone at] Show Other
  • Migliore, Michele [Michele.Migliore at] Show Other
Other categories referring to Ventral medial entorhinal cortical stellate neuron model: the role of T-type Ca2+ and persistent Na+
Revisions: 9
Last Time: 6/22/2023 10:10:34 AM
Reviewer: System Administrator
Owner: Michele Migliore