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Data
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Striatum D1 Striosome and Matrix Upstates (Prager et al., 2020)
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Daniel Dorman
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"...We show that dopamine oppositely shapes responses to convergent excitatory inputs in mouse striosome and matrix striatal spiny projection neurons (SPNs). Activation of postsynaptic D1 dopamine receptors promoted the generation of long-lasting synaptically evoked 'up-states' in matrix SPNs but opposed it in striosomes, which were more excitable under basal conditions. Differences in dopaminergic modulation were mediated, in part, by dendritic voltage-gated calcium channels (VGCCs): pharmacological manipulation of L-type VGCCs reversed compartment-specific responses to D1 receptor activation..."
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Neostriatum medium spiny direct pathway GABA cell Show
Other
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Neuron or other electrically excitable cell Show
Other
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Prager EM, Dorman DB, Hobel ZB, Malgady JM, Blackwell KT, Plotkin JL (2020) Show
Other
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ddorman@gmu.edu
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