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Coincident glutamatergic depolarization effects on Cl- dynamics (Lombardi et al, 2021)
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Werner Kilb
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"... we used compartmental biophysical models of Cl- dynamics simulating either a simple ball-and-stick topology or a reconstructed CA3 neuron. These computational experiments demonstrated that glutamatergic co-stimulation enhances GABA receptor-mediated Cl- influx at low and attenuates or reverses the Cl- efflux at high initial [Cl-]i. The size of glutamatergic influence on GABAergic Cl--fluxes depends on the conductance, decay kinetics, and localization of glutamatergic inputs. Surprisingly, the glutamatergic shift in GABAergic Cl--fluxes is invariant to latencies between GABAergic and glutamatergic inputs over a substantial interval..."
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Hippocampus CA3 pyramidal GLU cell Show
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Lombardi A, Jedlicka P, Luhmann HJ, Kilb W (2021) Show
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Jedlicka, Peter [jedlicka at em.uni-frankfurt.de] Show
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Kilb, Werner [wkilb at uni-mainz.de] Show
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wkilb@uni-mainz.dew
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