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Coincident glutamatergic depolarization effects on Cl- dynamics (Lombardi et al, 2021)
Werner Kilb
"... we used compartmental biophysical models of Cl- dynamics simulating either a simple ball-and-stick topology or a reconstructed CA3 neuron. These computational experiments demonstrated that glutamatergic co-stimulation enhances GABA receptor-mediated Cl- influx at low and attenuates or reverses the Cl- efflux at high initial [Cl-]i. The size of glutamatergic influence on GABAergic Cl--fluxes depends on the conductance, decay kinetics, and localization of glutamatergic inputs. Surprisingly, the glutamatergic shift in GABAergic Cl--fluxes is invariant to latencies between GABAergic and glutamatergic inputs over a substantial interval..."
  • Hippocampus CA3 pyramidal GLU cell Show Other
  • Lombardi A, Jedlicka P, Luhmann HJ, Kilb W (2021) Show Other
  • Jedlicka, Peter [jedlicka at em.uni-frankfurt.de] Show Other
  • Kilb, Werner [wkilb at uni-mainz.de] Show Other
wkilb@uni-mainz.dew
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Revisions: 5
Last Time: 1/20/2021 10:24:26 AM
Reviewer: Robert A McDougal
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