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Data
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Reduced-morphology model of CA1 pyramidal cells optimized + validated w/ HippoUnit (Tomko et al '21)
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Matus Tomko
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Here we employ the HippoUnit tests to optimize and validate our new compartmental model with reduced morphology. We show that our model is able to account for the following six well-established characteristic anatomical and physiological properties of CA1 pyramidal cells: (1) The reduced dendritic morphology contains all major dendritic branch classes. In addition to anatomy, the model reproduces also 5 key physiological features, including (2) somatic electrophysiological responses, (3) depolarization block, (4) EPSP attenuation (5) action potential (AP) backpropagation, and (6) synaptic integration at oblique dendrites.
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Hippocampus CA1 pyramidal GLU cell Show
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Neuron or other electrically excitable cell Show
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Tomko M, Benuskova L, Jedlicka P (2021) Show
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matus.tomko@fmph.uniba.sk
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