SenseLab
Computational model
  Data
Ambient glutamate shapes AMPA receptor responses to simulated transients (Balmer et al. 2021)
Tim Balmer
AMPA_glutamate [13188]
To explore how ambient glutamate contributes to the generation of ultra-slow signaling through AMPARs at the cerebellar unipolar brush cell synapse, we created this 13-state kinetic model in NEURON. A tool was also created to produce trains of glutamate concentration transients using 2D or 3D diffusion equations, a sum of up to 3 exponentials, or an alpha function that can be applied to the AMPA receptor model. After compiling the model using mkrndll, run 'mosinit_fast-flow.hoc' to simulate fast application of glutamate to the AMPA receptor model. 'mosinit_GluTransTrainTool_demo.hoc' opens a session where trains of synaptic glutamate transients can be created using various equations. The top panel shows the glutamate concentration transients (in mM) and the bottom panel shows the AMPA receptor mediated currents (in nA).
  • Balmer TS, Borges-Merjane C, Trussell LO (2021) Show Other
timothy.balmer@asu.edu
Desensitization
https://www.biorxiv.org/content/10.1101/2020.10.23.352120v1
False
False
Other categories referring to Ambient glutamate shapes AMPA receptor responses to simulated transients (Balmer et al. 2021)
Revisions: 7
Last Time: 2/22/2021 11:09:47 AM
Reviewer: Robert A McDougal
Owner: Tom Morse - MoldelDB admin