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Cardiac models of circadian rhythms in early afterdepolarizations & arrhythmias (Diekman & Wei 2021)
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Casey O. Diekman
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We fit a simplified Luo-Rudy model to voltage-clamp data showing a circadian rhythm in L-type calcium conductance. Simulations of the model (single-cell and 2-D spatial versions) suggest that circadian rhythms in early afterdepolarizations may contribute to daily rhythms in cardiac arrhythmias and sudden cardiac death.
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Neuron or other electrically excitable cell Show
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Diekman, Casey O. [casey.o.diekman at njit.edu] Show
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casey.o.diekman@njit.edu
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PMID: 33285114
DOI: 10.1016/j.bpj.2020.11.2264
Diekman and Wei (2021) Circadian Rhythms of Early Afterdepolarizations and Ventricular Arrhythmias in a Cardiomyocyte Model. Biophysical Journal 120:319-333.
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