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Human Cortical L5 Pyramidal Cell (Rich et al. 2021)
Scott Rich
This paper presents a full spiking, biophysically detailed multi-compartment model of a human cortical layer 5 (L5) pyramidal cell, where model development was primarily based on morphological and electrophysiological data from the same neuron. Focus was placed on capturing distinctly human dynamics of the h-channel and led to the articulation of a novel model of this channel's dynamics in humans. This led to an explanation for the surprising lack of subthreshold resonance seen in these cells in the human as opposed to rodent setting.
  • Neuron or other electrically excitable cell Show Other
  • Rich S, Moradi Chameh H, Sekulic V, Valiante TA, Skinner FK (2021) Show Other
  • Rich, Scott [sbrich at umich.edu] Show Other
sbrich@umich.edu
Rich S, Moradi Chameh H, Sekulic V, Valiante TA, Skinner FK. Modeling Reveals Human-Rodent Differences in H-Current Kinetics Influencing Resonance in Cortical Layer 5 Neurons. Cereb Cortex. 2021 Jan 5;31(2):845-872. doi: 10.1093/cercor/bhaa261. PMID: 33068000; PMCID: PMC7906797.
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Revisions: 5
Last Time: 3/23/2021 7:10:36 PM
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