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  Data
Olfactory bulb main mitral GLU cell
GM Shepherd, Synaptic Organization of the Brain, New York: Oxford University Press 1979.
337,271
The principal neuron of the vertebrate olfactory bulb. It has a primary dendrite that receives the sensory input from the olfactory nerve terminals in its distal dendritic tuft in the olfactory glomerulus. It processes this input at two levels: through interactions of its dendritic tuft dendrites with periglomerular cell interneurons at the glomerular level, and by means of interactions between its lateral dendrites and inhibitory granule cell interneurons at the cell body level. Through its axon it sends the output of the olfactory bulb to the olfactory cortex. It uses glutamate as its excitatory transmitter at both its dendritic and axonal synapses. It is modulated by central centrifugal brainstem and basal forebrain systems, acting mainly on the interneurons. Tufted cells are smaller versions of mitral cells, with distinct subtypes depending on location, dendritic properties and axonal targets. Mitral/tufted cells are equivalent to the principal neurons in the insect antennal lobe
129
 Neuronal Receptors (39)
  
SN Property present CF-Compartment Receptor Connect Note Publication facts
1 Yes Distal apical dendrite GabaB
2 Yes Proximal basal dendrite GabaB
3 Yes Middle basal dendrite NMDA Paired recordings in slices showed excitatory transmission mediated solely by transmitter spillover between mitral cells. Dendritic glutamate release causes self-excitation via local activation of NMDA receptors, and generates NMDA receptor-mediated responses in neighbouring cells. It is suggested that this simultaneous activation of neighbouring cells by a diffuse action of glutamate provides a mechanism for synchronizing olfactory principal cells
4 Yes Middle basal dendrite mGluR7 Possible
5 Yes Middle basal dendrite mGluR6 Possible
6 Yes Middle basal dendrite mGluR4 Possible
7 Yes Middle basal dendrite mGluR1 Auto-activation from glutamate released by mitral cell secondary dendrites
8 Yes Middle basal dendrite GabaA Identification of subunit mRNAs
9 Yes Proximal basal dendrite GabaA The kinetics of GABA currents were studied using flash photolysis of caged GABA
10 Yes Proximal basal dendrite NMDA Paired recordings in slices showed excitatory transmission mediated solely by transmitter spillover between mitral cells. Dendritic glutamate release causes self-excitation via local activation of NMDA receptors, and generates NMDA receptor-mediated responses in neighbouring cells. It is suggested that this simultaneous activation of neighbouring cells by a diffuse action of glutamate provides a mechanism for synchronizing olfactory principal cells
11 Yes Proximal basal dendrite AMPA The pharmacology and kinetics of glutamate sensitivity of mitral cells was studied using flash photolysis in rats
12 Yes Proximal basal dendrite mGluR1 Auto-activation from glutamate released by mitral cell secondary dendrites
13 Yes Distal basal dendrite GabaB
14 Yes Soma GabaA The kinetics of GABA currents were studied using flash photolysis of caged GABA
15 Yes Soma mGluR1 Auto-activation from glutamate released by mitral cell soma
16 Yes Distal basal dendrite GabaA Identification of subunit mRNAs
17 Yes Distal basal dendrite AMPA With a postembedding immunogold procedure, it has been found that these receptors do not appear to be concentrated in clusters on dendrites, suggesting that the presynaptic effects of glutamate are mediated by a small complement of extrasynaptic receptors
18 Yes Distal basal dendrite mGluR6 Possible
19 Yes Distal basal dendrite NMDA Paired recordings in slices showed excitatory transmission mediated solely by transmitter spillover between mitral cells. Dendritic glutamate release causes self-excitation via local activation of NMDA receptors, and generates NMDA receptor-mediated responses in neighbouring cells. It is suggested that this simultaneous activation of neighbouring cells by a diffuse action of glutamate provides a mechanism for synchronizing olfactory principal cells
20 Yes Distal basal dendrite mGluR7 Possible
21 Yes Distal basal dendrite mGluR4 Possible
22 Yes Middle basal dendrite AMPA With a postembedding immunogold procedure, it has been found that these receptors do not appear to be concentrated in clusters on dendrites, suggesting that the presynaptic effects of glutamate are mediated by a small complement of extrasynaptic receptors
23 Yes Distal basal dendrite mGluR1 Auto-activation from glutamate released by mitral cell secondary dendrites
24 Yes Middle apical dendrite NMDA Paired recordings in slices showed excitatory transmission mediated solely by transmitter spillover between mitral cells. Dendritic glutamate release causes self-excitation via local activation of NMDA receptors, and generates NMDA receptor-mediated responses in neighbouring cells. It is suggested that this simultaneous activation of neighbouring cells by a diffuse action of glutamate provides a mechanism for synchronizing olfactory principal cells
25 Yes Proximal apical dendrite NMDA The pharmacology and kinetics of glutamate sensitivity of mitral cells was studied using flash photolysis in rats
26 Yes Soma NMDA The pharmacology and kinetics of glutamate sensitivity of mitral cells was studied using flash photolysis in rats
27 Yes Distal apical dendrite Dopaminergic Receptor DA receptors in mitral cell dendrites implied by DA localization in PG dendrites presynaptic to mitral dendrites
28 Yes Distal apical dendrite AMPA Paired whole-cell recording revealed reciprocal excitatory connections between mitral cells. Pharmacological analysis suggested that it could be mediated by both AMPA and NMDA receptors
29 Yes Distal apical dendrite NMDA Paired whole-cell recording revealed reciprocal excitatory connections between mitral cells. Pharmacological analysis suggested that it could be mediated by both AMPA and NMDA receptors
30 Yes Distal apical dendrite GabaA Identification of subunit mRNAs
31 Yes Distal apical dendrite mGluR1 Auto-activation from glutamate released by mitral cell secondary dendrites
32 Yes Middle apical dendrite GabaA Identification of subunit mRNAs
33 Yes Proximal apical dendrite GabaA The kinetics of GABA currents were studied using flash photolysis of caged GABA
34 Yes Soma GabaB
35 Yes Middle apical dendrite Dopaminergic Receptor
36 Yes Middle basal dendrite GabaB
37 Yes Soma Kainate In an immunocytochemical study in zebrafish 60-70% of cells showed KA receptor mediated labelling
38 Yes Proximal apical dendrite GabaB
39 No Distal apical dendrite mGluR
 Neuronal Currents (33)
  
SN Property present CF-Compartment Current Connect Note Publication facts
1 Yes Middle basal dendrite I A By using dendritic recordings and calcium transients in rats it was shown that this current may control AP propagation in lateral dendrites
2 Yes Middle basal dendrite I Na,t By combining intracellular recordings and two-photon microscopy imaging of [Ca]i it was shown that AP propagate at full amplitude up to the most distal branches
3 Yes Proximal basal dendrite I N
4 Yes Proximal basal dendrite I Na,t By combining intracellular recordings and two-photon microscopy imaging of [Ca]i it was shown that AP propagate at full amplitude up to the most distal branches
5 Yes Axon hillock I Na,t Estimated: HH model slightly modified from Traub, 1982
6 Yes Axon hillock I K
7 Yes Axon fiber I Na,t Conduction of the action potential suggests there must be some Na channels there.
8 Yes Axon terminal I N inferred
9 Yes Proximal basal dendrite I A By using dendritic recordings and calcium transients in rats it was shown that this current may control AP propagation in lateral dendrites
10 Yes Soma I K Using whole-cell recordings, the kinetic properties of this current have been investigated in neurones from neonatal rats, which were retrogradely labelled and identified after enzymatic dissociation
11 Yes Distal basal dendrite I A By using dendritic recordings and calcium transients in rats it was shown that this current may control AP propagation in lateral dendrites
12 Yes Soma I K,leak Assumed.
13 Yes Soma I p,q
14 Yes Soma I L high threshold
15 Yes Soma I T low threshold
16 Yes Soma I A Using whole-cell recordings, the kinetic properties of this current have been investigated in neurones from neonatal rats, which were retrogradely labelled and identified after enzymatic dissociation
17 Yes Soma I K,Ca Unpublished data by Chen and Shepherd have revealed a long lasting after hyperpolarization following a train of action potentials. Using whole-cell recordings, the kinetic properties of this current have been investigated in neurones from neonatal rats, which were retrogradely labelled and identified after enzymatic dissociation
18 Yes Proximal apical dendrite I N
19 Yes Distal basal dendrite I Na,t By combining intracellular recordings and two-photon microscopy imaging of [Ca]i it was shown that AP propagate at full amplitude up to the most distal branches
20 Yes Distal basal dendrite I N Implied by data on more proximal dendritic regions; still to be tested
21 Yes Middle basal dendrite I N
22 Yes Distal apical dendrite I h report the presence and function of Ih.
23 Yes Soma I h report the presence and function of Ih.
24 Yes Distal apical dendrite I A
25 Yes Middle apical dendrite I A
26 Yes Proximal apical dendrite I A
27 Yes Soma I Na,t Somatic and Dendritic patch recordings showed an even density of Na channels (120pSum-2) up to 350 um from the soma along the primary dendrite to theorigin of the glomerular tuft
28 Yes Distal apical dendrite I Na,t By combining intracellular recordings and two-photon microscopy imaging of [Ca]i in rat it was shown that APs backpropagate at full amplitude up to the tuft
29 Yes Distal apical dendrite I N
30 Yes Middle apical dendrite I Na,t Dendritic patch recordings showed an even density of Na channels (120pSum-2) up to 350 um from the soma along the primary dendrite to theorigin of the glomerular tuft
31 Yes Middle apical dendrite I N
32 Yes Proximal apical dendrite I Na,t Dendritic patch recordings showed an even density of Na channels (120pSum-2) up to 350 um from the soma along the primary dendrite to theorigin of the glomerular tuft
33 Yes Middle apical dendrite I h report the presence and function of Ih.
 Neuronal Transmitters (8)
  
SN Property present CF-Compartment transmitter Connect Note Publication facts
1 Yes Middle basal dendrite Glutamate
2 Yes Proximal basal dendrite Glutamate
3 Yes Axon terminal Glutamate
4 Yes Distal basal dendrite Glutamate
5 Yes Soma Glutamate see also Felix and MacLennan, 1971).
6 Yes Distal apical dendrite Glutamate Implied by Glu released by other compartments of the mitral cell (Dale's law). Target (destination) is presumably PG cell dendrites in the glomerulus
7 Yes Middle apical dendrite Glutamate
8 Yes Proximal apical dendrite Glutamate
Other categories referring to Olfactory bulb main mitral GLU cell
Computational model.Model Neurons   (48)
Interneurons Connectivity.Principal Neurons   (2)
Pathological mechanism.Neuron   (2)
2 Objects Relationship (edge).Object Two (target)   (1)
Neural compartmental intracell.Neuron   (1)
Cell Type.NeuronDB Neuron   (1)
Neuronal Structure.Neurons   (1)
Revisions: 10
Last Time: 9/29/2015 1:18:54 PM
Reviewer: System Administrator
Owner: System Administrator