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Leaky Integrate and Fire Neuron Model of Context Integration (Calvin, Redish accepted)
Olivia Louise Calvin
The maintenance of the contextual information has been shown to be sensitive to changes in excitation-inhbition (EI) balance. We constructed a multi-structure, biophysically-realistic agent that could perform context-integration as is assessed by the dot probe expectancy task. The agent included a perceptual network, a working memory network, and a decision making system and was capable of successfully performing the dot probe expectancy task. Systemic manipulation of the agent’s EI balance produced localized dysfunction of the memory structure, which resulted in schizophrenia-like deficits at context integration.
  • Abstract integrate-and-fire leaky neuron Show Other
ocalvin@umn.edu
Context Integration
Calvin, Olivia [ocalvin@umn.edu]
Calvin, O.L. & Redish, A.D. (2021). Global disruption in excitation-inhibition balance can cause localized network dysfunction and schizophrenia-like context-integration deficits. PLoS Computational Biology. TBD
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Revisions: 11
Last Time: 5/13/2021 5:52:45 PM
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Owner: Tom Morse - MoldelDB admin