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Dynamics of ramping bursts in a respiratory pre-Botzinger Complex model (Abdulla et al, accepted)
Jonathan Rubin
prelramp [1910]
This single-neuron model is, to the authors' knowledge, the first to capture the pre-inspiratory ramping aspects of preBotzinger Complex inspiratory neurons' activity patterns, in which relatively slow tonic spiking gradually progresses to faster spiking and a full-blown burst, with a corresponding gradual development of an underlying plateau potential. The key to this pattern is the incorporation of the dynamics of the extracellular potassium ion concentration, which is here integrated into an existing model for pre-BotC neuron bursting along with some parameter adjustments. Using fast-slow decomposition, this activity can be shown to be a form of parabolic bursting, but with burst termination at a homoclinic bifurcation rather than at a SNIC bifurcation.
  • Neuron or other electrically excitable cell Show Other
  • Abdulla M, Phillips R, Rubin J (2021) Show Other
  • Abdulla, Muhammad [muhammadabdulla at ufl.edu] Show Other
  • Phillips, Ryan [ryanp at pitt.edu] Show Other
  • Rubin, Jonathan E [jonrubin at pitt.edu] Show Other
jonrubin@pitt.edu
dynamic extracellular potassium
False
False
Other categories referring to Dynamics of ramping bursts in a respiratory pre-Botzinger Complex model (Abdulla et al, accepted)
Revisions: 6
Last Time: 9/30/2021 6:42:26 PM
Reviewer: System Administrator
Owner: Tom Morse - MoldelDB admin