SenseLab
Computational model
  Data
DG adult-born granule cell: nonlinear a5-GABAARs control AP firing (Lodge et al, accepted)
Jan Michael Schulz
GABA can depolarize immature neurons close to the action potential (AP) threshold in development and adult neurogenesis. Nevertheless, GABAergic synapses effectively inhibit AP firing in newborn granule cells of the adult hippocampus as early as 2 weeks post mitosis. Parvalbumin and dendrite-targeting somatostatin interneurons activate a5-subunit containing GABAA receptors (a5-GABAARs) in young neurons, which show a voltage dependent conductance profile with increasing conductance around the AP threshold. The present computational models show that the depolarized GABA reversal potential promotes NMDA receptor activation. However, the voltage-dependent conductance of a5-GABAARs in young neurons is crucial for inhibition of AP firing to generate balanced and sparse firing activity.
  • Neuron or other electrically excitable cell Show Other
  • Lodge M, Hernandez MC, Schulz JM, Bischofberger J (2021) Show Other
j.schulz@unibas.ch
Meredith Lodge, Maria-Clemencia Hernandez, Jan M. Schulz, and Josef Bischofberger, Sparsification of AP firing in adult-born hippocampal granule cells via voltage-dependent a5-GABAA receptors CELL REPORTS 2021
False
False
Other categories referring to DG adult-born granule cell: nonlinear a5-GABAARs control AP firing (Lodge et al, accepted)
Revisions: 5
Last Time: 8/24/2021 12:42:24 PM
Reviewer: Robert A McDougal
Owner: Jan Michael Schulz