BrainPharm: Computational model - DG adult-born granule cell: nonlinear a5-GABAARs control AP firing (Lodge et al, 2021)

Computational model

Data

Name

DG adult-born granule cell: nonlinear a5-GABAARs control AP firing (Lodge et al, 2021)

Submitter name

Jan Michael Schulz

Pipeline ID

Model File

Lodge_2021_Cell_Rep_GC_Models [36056]

Notes

GABA can depolarize immature neurons close to the action potential (AP) threshold in development and adult neurogenesis. Nevertheless, GABAergic synapses effectively inhibit AP firing in newborn granule cells of the adult hippocampus as early as 2 weeks post mitosis. Parvalbumin and dendrite-targeting somatostatin interneurons activate a5-subunit containing GABAA receptors (a5-GABAARs) in young neurons, which show a voltage dependent conductance profile with increasing conductance around the AP threshold. The present computational models show that the depolarized GABA reversal potential promotes NMDA receptor activation. However, the voltage-dependent conductance of a5-GABAARs in young neurons is crucial for inhibition of AP firing to generate balanced and sparse firing activity.

Model Neurons

Dentate gyrus granule GLU cell Show Other

More Cells

Model Currents

I K Show Other
I Krp Show Other
I Na,t Show Other

Model Receptors

AMPA Show Other
GabaA Show Other
NMDA Show Other

Model Type

Neuron or other electrically excitable cell Show Other

Model Concept

Action Potentials Show Other
Detailed Neuronal Models Show Other
Development Show Other
Neurogenesis Show Other
Pattern Separation Show Other
Synaptic Integration Show Other

Simulator software

NEURON Show Other

Model papers

Lodge M, Hernandez MC, Schulz JM, Bischofberger J (2021) Show Other

Gene

hg folder name (applicable when in ModelDB hg)

Region Organism

Dentate gyrus Show Other

Model ID Number

Gap Junctions

Implemented by

Schulz, Jan M [j.schulz at unibas.ch] Show Other
Bischofberger, Josef Show Other

Public Submitter Email Address

j.schulz@unibas.ch

Other Neuron

Model Neurotransmitters

Gaba Show Other
Glutamate Show Other

Other Receptor

Other Current

Other Neurotransmitter

Other Model Type

Other Concept

Other Simulator

Other Implementer

Alternative Version

Citation

Meredith Lodge, Maria-Clemencia Hernandez, Jan M. Schulz, and Josef Bischofberger, Sparsification of AP firing in adult-born hippocampal granule cells via voltage-dependent a5-GABAA receptors CELL REPORTS 2021

Default File Notes

Other Gene

Simulation Platform ID

Has Model View

False

Component

RAM

Hide Auto-launch button

False

Run Protocols

ICG Channel Details

Species

Other categories referring to DG adult-born granule cell: nonlinear a5-GABAARs control AP firing (Lodge et al, 2021)

Revisions:	7
Last Time:	2/13/2023 10:10:32 AM
Reviewer:	Rhea Rajvansh
Owner:	Jan Michael Schulz