Computational model
Spreading Depolarization in Brain Slices (Kelley et al. 2022)
Craig Kelley
A tissue-scale model of spreading depolarization (SD) in brain slices. We used the NEURON simulator's reaction-diffusion framework to implement embed thousands of neurons (based on the the model from Wei et al. 2014) in the extracellular space of a brain slice, which is itself embedded in an bath solution. We initiate SD in the slice by elevating extracellular K+ in a spherical region at the center of the slice. Effects of hypoxia and propionate on the slice were modeled by appropriate changes to the volume fraction and tortuosity of the extracellular space and oxygen/chloride concentrations.
  • Kelley C, Newton AJH, Hrabetova S, McDougal RA, Lytton WW (2022) Show Other
  • Kelley, Craig Show Other
  • Newton, Adam J H [adam.newton at] Show Other
  • Lytton, William [bill.lytton at] Show Other
  • McDougal, Robert [robert.mcdougal at] Show Other
Other categories referring to Spreading Depolarization in Brain Slices (Kelley et al. 2022)
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