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Data
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A focal seizure model with ion concentration changes (Gentiletti et al., 2022)
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Piotr Suffczynski
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Computer model was used to investigate the possible mechanisms of seizure initiation, progression and termination. The model was developed by complementing the Hodgkin-Huxley equations with activity-dependent changes in intra- and extracellular ion concentrations. The model incorporates a number of ionic mechanisms such as: active and passive membrane currents, inhibitory synaptic GABAA currents, Na/K pump, KCC2 cotransporter, glial K buffering, radial diffusion between extracellular space and bath, and longitudinal diffusion between dendritic and somatic compartments in pyramidal cells.
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Entorhinal cortex pyramidal cell Show
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Entorhinal cortex fast-spiking interneuron Show
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Gentiletti D, de Curtis M, Gnatkovsky V, Suffczynski P (2022) Show
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Suffczynski, Piotr [Piotr.Suffczynski at fuw.edu.pl] Show
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Gentiletti, Damiano [gentiletti.damiano at gmail.com] Show
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piotr.suffczynski@fuw.edu.pl
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Gentiletti D, de Curtis M, Gnatkovsky V and Suffczynski P (2022), Focal seizures are organized by feedback between neural activity and ion concentration changes. eLife
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