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A focal seizure model with ion concentration changes (Gentiletti et al., accepted)
Piotr Suffczynski
SeizureDyn2022 [181792]
Computer model was used to investigate the possible mechanisms of seizure initiation, progression and termination. The model was developed by complementing the Hodgkin-Huxley equations with activity-dependent changes in intra- and extracellular ion concentrations. The model incorporates a number of ionic mechanisms such as: active and passive membrane currents, inhibitory synaptic GABAA currents, Na/K pump, KCC2 cotransporter, glial K buffering, radial diffusion between extracellular space and bath, and longitudinal diffusion between dendritic and somatic compartments in pyramidal cells.
  • Entorhinal cortex pyramidal cell Show Other
  • Entorhinal cortex fast-spiking interneuron Show Other
  • Gentiletti D, de Curtis M, Gnatkovsky V, Suffczynski P (accepted) Show Other
  • Suffczynski, Piotr [Piotr.Suffczynski at fuw.edu.pl] Show Other
  • Gentiletti, Damiano [gentiletti.damiano at gmail.com] Show Other
piotr.suffczynski@fuw.edu.pl
Gentiletti D, de Curtis M, Gnatkovsky V and Suffczynski P (2022), Focal seizures are organized by feedback between neural activity and ion concentration changes. eLife
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Revisions: 5
Last Time: 7/29/2022 3:57:16 PM
Reviewer: System Administrator
Owner: Piotr Suffczynski