Computational model
ELL Medium Ganglion Cell (Mormyrid fish) (Muller et al, accepted)
Salomon Z Muller
"In addition to the action potentials used for axonal signaling, many neurons generate dendritic 'spikes' associated with synaptic plasticity. However, in order to control both plasticity and signaling, synaptic inputs must be able to differentially modulate the firing of these two spike types. Here we investigate this issue in the electrosensory lobe (ELL) of weakly electric mormyrid fish, where separate control over axonal and dendritic spikes is essential for the transmission of learned predictive signals from inhibitory interneurons to the output stage of the circuit. Through a combination of experimental and modeling studies, we uncover a novel mechanism by which sensory input selectively modulates the rate of dendritic spiking by adjusting the amplitude of backpropagating axonal action potentials. Interestingly, this mechanism does not require spatially segregated synaptic inputs or dendritic compartmentalization, but relies instead on an electrotonically distant spike initiation site in the axon—a common biophysical feature of neurons. "
  • Muller SZ, Abbott LF, Sawtell NB (accepted) Show Other
  • Muller, Salomon Z [szm2106 at] Show Other
Muller SZ, Abbott LF and Sawtell NB, Interaction between Dendritic and Axonal Spiking Reconciles Homeostasis and Learning - under review.
Other categories referring to ELL Medium Ganglion Cell (Mormyrid fish) (Muller et al, accepted)
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