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DRG nociceptors from wild-type and Fhf2-KO mice. Fhf2 gene knockout blocks heat nociception.
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Mitchell Goldfarb
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We employ electrophysiological and computational methods to show that the heat nociception deficit in Fhf2 knockout mice can be explained by the combined effects of elevated temperature and FHF2 deficiency on the fast inactivation gating of Na v 1.7 and tetrodotoxin-resistant sodium channels expressed in dorsal root ganglion C-fibers.
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Marra C, Hartke TV, Ringkamp M, Goldfarb M (in press) Show
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Goldfarb, Mitchell goldfarb at genectr.hunter.cuny.edu] Show
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goldfarb@genectr.hunter.cuny.edu
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PMID: 36607284; DOI: 10.1097/j.pain.0000000000002822
C Marra, TV Hartke, M Ringkamp, M Goldfarb (2023) Enhanced sodium channel inactivation by temperature and FHF2 deficiency blocks heat nociception. Pain, in press.
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