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Data
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Single neuron models of four types of L1 mouse Interneurons: Canpy, NGFC, alpha7 and VIP cells
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John Hongyu Meng
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Neocortical Layer 1 (L1) consists of the distal dendrites of pyramidal cells and GABAergic interneurons (INs) and receives extensive long-range “top-down” projections, but L1 INs remain poorly understood. In this work, we systematically examined the distinct dominant electrophysiological features for four unique IN subtypes in L1 that were previously identified from mice of either gender: Canopy cells
show an irregular firing pattern near rheobase; Neurogliaform cells (NGFCs) are
late-spiking, and their firing rate accelerates during current injections; cells with strong
expression of the a7 nicotinic receptor (a7 cells), display onset (rebound) bursting;
vasoactive intestinal peptide (VIP) expressing cells exhibit high input resistance, strong
adaptation, and irregular firing. Computational modeling revealed that these diverse
neurophysiological features could be explained by an extended
exponential-integrate-and-fire neuron model with varying contributions of a slowly
inactivating K+ channel (SIK), a T-type Ca2+ channel, and a spike-triggered
Ca2+-dependent K+ channel. In particular, we show that irregular firing results from
square-wave bursting through a fast-slow analysis. Furthermore, we demonstrate that
irregular firing is frequently observed in VIP cells due to the interaction between strong
adaptation and a SIK channel. At last, we reveal that the VIP and a7 cell models
resonant with Alpha/Theta band input through a dynamic gain analysis.
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Abstract integrate-and-fire leaky neuron Show
Other
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Neuron or other electrically excitable cell Show
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Meng JH, Schuman B, Rudy B, Wang XJ Show
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john.meng@nyu.edu
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Neurocortex S1 L1 Interneurons;
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slow-inactivation Potassium channel
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John Hongyu Meng
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https://www.biorxiv.org/content/10.1101/2022.08.23.505010v2.abstract
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