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Cerebellum Purkinje cell
Cajal, S.R., Histology of the Nervous System, Volume 1, New York: Oxford University Press 1995.
18
 Neuronal Receptors (12)
  
SN Property present CF-Compartment Receptor Connect Note Publication facts
1 Yes Middle equivalent dendrite Glutamate Climbing Fiber terminals (T) and Parallel Fiber terminals (T) Ionophoretic glutamate applied to dendrites depolarizes Purkinje cells. Glu is released from parallel fibers of granule cells
2 Yes Middle equivalent dendrite GabaA Stellate Cell terminals (T) Recordings in slices showed that GABA inhibition was mediated by GABA(B) receptors in the dendrites and GABA(A) receptors in the soma and dendrites
3 Yes Proximal equivalent dendrite Glutamate Climbing Fiber terminals (T) Ionophoretic glutamate applied to dendrites depolarizes Purkinje cells. Glu is released from parallel fibers of granule cells
4 Yes Proximal equivalent dendrite GabaA Stellate Cell terminals (T) Recordings in slices showed that GABA inhibition was mediated by GABA(B) receptors in the dendrites and GABA(A) receptors in the soma and dendrites
5 Yes Axon hillock Gaba Basket Cell terminals (T) for review see Llinas and Walton 1998).
6 Yes Soma Gaba Basket Cell terminals (T) for review see Llinas and Walton 1998).
7 Yes Distal equivalent dendrite GabaA Stellate Cell terminals (T) Recordings in slices showed that GABA inhibition was mediated by GABA(B) receptors in the dendrites and GABA(A) receptors in the soma and dendrites
8 Yes Distal equivalent dendrite Glutamate Parallel Fiber terminals (T) Ionophoretic glutamate applied to dendrites depolarizes Purkinje cells. Glu is released from parallel fibers of granule cells
9 Yes Distal equivalent dendrite GabaB The cellular localization of GABAB binding was investigated using lesion techniques. It was suggested that the majority of cerebellar molecular layer GABAB binding sites are located on Purkinje cell dendrites. During development binding in the molecular layer peaks between postnatal day 14 and postnatal day 28 and then decreases to adult levels
10 Yes Middle equivalent dendrite GabaB The cellular localization of GABAB binding was investigated using lesion techniques. It was suggested that the majority of cerebellar molecular layer GABAB binding sites are located on Purkinje cell dendrites. During development binding in the molecular layer peaks between postnatal day 14 and postnatal day 28 and then decreases to adult levels
11 Yes Proximal equivalent dendrite GabaB The cellular localization of GABAB binding was investigated using lesion techniques. It was suggested that the majority of cerebellar molecular layer GABAB binding sites are located on Purkinje cell dendrites. During development binding in the molecular layer peaks between postnatal day 14 and postnatal day 28 and then decreases to adult levels
12 Yes Soma GabaA Recordings in slices showed that GABA inhibition was mediated by GABA(B) receptors in the dendrites and GABA(A) receptors in the soma and dendrites
 Neuronal Currents (33)
  
SN Property present CF-Compartment Current Connect Note Publication facts
1 Distal equivalent dendrite I Na,t
2 Middle equivalent dendrite I Na,t
3 Yes Proximal equivalent dendrite I Na,t
4 Yes Middle equivalent dendrite I L high threshold reviewed in McCormick 1998).
5 Yes Middle equivalent dendrite I K Increased conductance may follow Ca impulses (Llinas and Walton 1998).
6 Yes Middle equivalent dendrite I K,Ca Increased conductance may follow Ca impulses (Llinas and Walton 1998).
7 Yes Middle equivalent dendrite I p,q Intradendritic recordings show Ca-dependent plateau potentials and Ca impulses
8 Yes Proximal equivalent dendrite I K,Ca Llinas and Walton 1990).
9 Yes Proximal equivalent dendrite I p,q Intradendritic recordings show Ca-dependent plateau potentials and Ca impulses
10 Yes Proximal equivalent dendrite I K Increased conductance may follow Ca impulses (Llinas and Walton 1998).
11 Yes Proximal equivalent dendrite I L high threshold reviewed in Llinas and Walton, 1990).
12 Yes Axon hillock I K
13 Yes Axon hillock I Na,t The kinetics properties of this current were studied using whole-cell recording from dissociated neurons. Unlike other cells, recovery from inactivation was accompanied by a sizeable ionic current. It was suggested that the current flowing during this recovery may depolarize the cells immediately after an AP, promoting the typical high-frequency firing of these neurons (complex spike)
14 Yes Axon fiber I Na,t
15 Yes Axon terminal I N
16 Yes Soma I Na,p Sensitive to TTX. This plateau potential underlies impulse bursting
17 Yes Soma I A Probably.
18 Yes Soma I Na,t
19 Yes Soma I K,Ca reviewed in Llinas and Walton, 1990).
20 Yes Soma I K quote from the review in Llinas and Walton 1990).
21 Yes Soma I T low threshold Suggested.
22 Yes Distal equivalent dendrite I K,Ca Increased conductance may follow Ca impulses (Llinas and Walton 1998).
23 Yes Distal equivalent dendrite I L high threshold reviewed in McCormick 1998).
24 Yes Distal equivalent dendrite I A
25 Yes Distal equivalent dendrite I K Increased conductance may follow Ca impulses (Llinas and Walton 1998).
26 Yes Distal equivalent dendrite I p,q Intradendritic recordings show Ca-dependent plateau potentials and Ca impulses
27 Yes Proximal equivalent dendrite I Potassium Macropatch clamp and intracellular recordings in guinea pigs suggested that the pattern of Ca2+ spike firing in the dendrites of Purkinje cells is dynamically modulated by a highly aminopyridine-sensitive K+ current, and probably also by a Ca2+-activated potassium current
28 Yes Middle equivalent dendrite I Potassium Macropatch clamp and intracellular recordings in guinea pigs suggested that the pattern of Ca2+ spike firing in the dendrites of Purkinje cells is dynamically modulated by a highly aminopyridine-sensitive K+ current, and probably also by a Ca2+-activated potassium current
29 Yes Distal equivalent dendrite I Potassium Macropatch clamp and intracellular recordings in guinea pigs suggested that the pattern of Ca2+ spike firing in the dendrites of Purkinje cells is dynamically modulated by a highly aminopyridine-sensitive K+ current, and probably also by a Ca2+-activated potassium current
30 Yes Distal equivalent dendrite I Calcium The presence of Calcium channels was directly demonstrated by imaging studies
31 Yes Middle equivalent dendrite I Calcium The presence of Calcium channels was directly demonstrated by imaging studies
32 Yes Proximal equivalent dendrite I Calcium The presence of Calcium channels was directly demonstrated by imaging studies
33 Yes Soma I Calcium The presence of Calcium channels was directly demonstrated by imaging studies
 Neuronal Transmitters (1)
  
SN Property present CF-Compartment transmitter Connect Note Publication facts
1 Yes Axon terminal Gaba
Other categories referring to Cerebellum Purkinje cell
Computational model.Model Neurons   (42)
Interneurons Connectivity.Principal Neurons   (1)
Pathological mechanism.Neuron   (1)
2 Objects Relationship (edge).Object Two (target)   (1)
Cell Type.NeuronDB Neuron   (1)
Neuronal Structure.Neurons   (1)
Revisions: 8
Last Time: 6/29/2018 3:04:27 PM
Reviewer: Gordon Shepherd
Owner: System Administrator