BrainPharm: Computational model - Active dendrites and spike propagation in a hippocampal interneuron (Saraga et al 2003)

Computational model

Data

Name

Active dendrites and spike propagation in a hippocampal interneuron (Saraga et al 2003)

Submitter name

Pipeline ID

Model File

OLMmodel_r3 [37071]

Notes

We create multi-compartment models of an Oriens-Lacunosum/Moleculare (O-LM) hippocampal interneuron using passive properties, channel kinetics, densities and distributions specific to this cell type, and explore its signaling characteristics. We find that spike initiation depends on both location and amount of input, as well as the intrinsic properties of the interneuron. Distal synaptic input always produces strong back-propagating spikes whereas proximal input could produce both forward and back-propagating spikes depending on the input strength. Please see paper for more details.

Model Neurons

Hippocampus CA1 interneuron oriens alveus GABA cell Show Other

More Cells

Model Currents

I Na,t Show Other
I A Show Other
I K Show Other
I h Show Other

Model Receptors

AMPA Show Other

Model Type

Neuron or other electrically excitable cell Show Other

Model Concept

Action Potential Initiation Show Other
Dendritic Action Potentials Show Other
Active Dendrites Show Other
Influence of Dendritic Geometry Show Other
Detailed Neuronal Models Show Other
Action Potentials Show Other

Simulator software

NEURON Show Other

Model papers

Saraga F, Wu CP, Zhang L, Skinner FK (2003) Show Other

Gene

hg folder name (applicable when in ModelDB hg)

OLMmodel

Region Organism

Model ID Number

Gap Junctions

Implemented by

Saraga, Fernanda [Fernanda.Saraga at utoronto.ca] Show Other

Public Submitter Email Address

Other Neuron

Model Neurotransmitters

Other Receptor

Other Current

Other Neurotransmitter

Other Model Type

Other Concept

Other Simulator

Other Implementer

Alternative Version

Citation

Default File Notes

Other Gene

Simulation Platform ID

148

Has Model View

True

Component

RAM

Hide Auto-launch button

False

Run Protocols

ICG Channel Details

Species

Other categories referring to Active dendrites and spike propagation in a hippocampal interneuron (Saraga et al 2003)

Revisions:	32
Last Time:	8/30/2016 4:11:51 PM
Reviewer:	Tom Morse - MoldelDB admin
Owner:	Tom Morse - MoldelDB admin