BrainPharm: Computational model - Burst induced synaptic plasticity in Apysia sensorimotor neurons (Phares et al 2003)

Computational model

Data

Name

Burst induced synaptic plasticity in Apysia sensorimotor neurons (Phares et al 2003)

Submitter name

Pipeline ID

Model File

Phares [?]

Notes

The Aplysia sensorimotor synapse is a key site of plasticity for several simple forms of learning. Intracellular stimulation of sensory neurons to fire a burst of action potentials at 10 Hz for 1 sec led to significant homosynaptic depression of postsynaptic responses. During the burst, the steady-state depressed phase of the postsynaptic response, which was only 20% of the initial EPSP of the burst, still contributed to firing the motor neuron. To explore the functional contribution of transient homosynaptic depression to the response of the motor neuron, computer simulations of the sensorimotor synapse with and without depression were compared. Depression allowed the motor neuron to produce graded responses over a wide range of presynaptic input strength. Thus, synaptic depression increased the dynamic range of the sensorimotor synapse and can, in principle, have a profound effect on information processing. Please see paper for results and details.

Model Neurons

More Cells

Aplysia sensory neuron Show Other
Aplysia motor neuron Show Other

Model Currents

I Na,t Show Other
I N Show Other
I A Show Other
I K Show Other
I Calcium Show Other
I A, slow Show Other

Model Receptors

AMPA Show Other

Model Type

Realistic Network Show Other

Model Concept

Synaptic Plasticity Show Other
Action Potentials Show Other
Facilitation Show Other
Depression Show Other
Invertebrate Show Other
Sensory processing Show Other

Simulator software

SNNAP Show Other

Model papers

Phares GA, Antzoulatos EG, Baxter DA, Byrne JH (2003) Show Other

Gene

hg folder name (applicable when in ModelDB hg)

Region Organism

Aplysia Show Other

Model ID Number

Gap Junctions

Implemented by

Phares, Gregg A [gregg.a.phares at uth.tmc.edu] Show Other

Public Submitter Email Address

Other Neuron

Model Neurotransmitters

Other Receptor

Other Current

Other Neurotransmitter

Other Model Type

Other Concept

Other Simulator

Other Implementer

Alternative Version

Citation

Default File Notes

Other Gene

Simulation Platform ID

Has Model View

False

Component

RAM

Hide Auto-launch button

False

Run Protocols

ICG Channel Details

Species

Aplysia Show Other

Other categories referring to Burst induced synaptic plasticity in Apysia sensorimotor neurons (Phares et al 2003)

Revisions:	26
Last Time:	2/26/2019 10:06:02 AM
Reviewer:	Tom Morse - MoldelDB admin
Owner:	Tom Morse - MoldelDB admin