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I A in Kenyon cells resemble Shaker currents (Pelz et al 1999)
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Cultured Kenyon cells from the mushroom body of the honeybee,
Apis mellifera, show a voltage-gated, fast transient K1 current that is
sensitive to 4-aminopyridine, an A current. The kinetic properties of
this A current and its modulation by extracellular K1 ions were
investigated in vitro with the whole cell patch-clamp technique. The
A current was isolated from other voltage-gated currents either pharmacologically
or with suitable voltage-clamp protocols. Hodgkin- and
Huxley-style mathematical equations were used for the description of
this current and for the simulation of action potentials in a Kenyon cell
model. The data of the A
current were incorporated into a reduced computational model of the
voltage-gated currents of Kenyon cells. In addition, the model contained
a delayed rectifier K current, a Na current, and a leakage
current. The model reproduces several experimental features and makes
predictions. See paper for details and results.
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Neuron or other electrically excitable cell Show
Other
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Pelz C, Jander J, Rosenboom H, Hammer M, Menzel R (1999) Show
Other
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