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Kinetic NMDA receptor model (Kampa et al 2004)
NMDA_Mg [?]
This kinetic NMDA receptor model is based on voltage-clamp recordings of NMDA receptor-mediated currents in nucleated patches of rat neocortical layer 5 pyramidal neurons (Kampa et al 2004 J Physiol), this model was fit with AxoGraph directly to experimental recordings in order to obtain the optimal values for the parameters. The demo shows the behaviour of a kinetic NMDA receptor model reproducing the data in figure 2. The NMDA receptor model uses realistic rates of magnesium block and its effects on channel desensitisation. Presynaptic transmitter release is necessary for glutamate binding to the receptor. This model was written by Bjoern Kampa, Canberra, 2004.
  • Neocortex V1 L6 pyramidal corticothalamic GLU cell Show Other
  • Kampa BM, Clements J, Jonas P, Stuart GJ (2004) Show Other
  • Kampa, Bjorn M [Bjoern.Kampa at anu.edu.au] Show Other
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Revisions: 12
Last Time: 2/15/2014 11:21:53 PM
Reviewer: Robert A McDougal
Owner: Tom Morse - MoldelDB admin