Computational model
Fast oscillations in inhibitory networks (Maex, De Schutter 2003)
We observed a new phenomenon of resonant synchronization in computer-simulated networks of inhibitory neurons in which the synaptic current has a delayed onset, reflecting finite spike propagation and synaptic transmission times. At the resonant level of network excitation, all neurons fire synchronously and rhythmically with a period approximately four times the mean delay of the onset of the inhibitory synaptic current. ... By varying the axonal delay of the inhibitory connections, networks with a realistic synaptic kinetics can be tuned to frequencies from 40 to >200 Hz. ... We conclude that the delay of the synaptic current is the primary parameter controlling the oscillation frequency of inhibitory networks and propose that delay-induced synchronization is a mechanism for fast brain rhythms that depend on intact inhibitory synaptic transmission.
  • Cerebellum interneuron granule GLU cell Show Other
  • Maex, Reinoud [reinoud at] Show Other
Other categories referring to Fast oscillations in inhibitory networks (Maex, De Schutter 2003)
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Last Time: 10/9/2008 4:29:46 PM
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