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LTP in cerebellar mossy fiber-granule cell synapses (Saftenku 2002)
lsimp2 [?]
We simulated synaptic transmission and modified a simple model of long-term potentiation (LTP) and long-term depression (LTD) in order to describe long-term plasticity related changes in cerebellar mossy fiber-granule cell synapses. In our model, protein autophosphorylation, leading to the maintenance of long-term plasticity, is controlled by Ca2+ entry through the NMDA receptor channels. The observed nonlinearity in the development of long-term changes of EPSP in granule cells is explained by the difference in the rate constants of two independent autocatalytic processes.
  • Saftenku, Elena [esaft at biph.kiev.ua] Show Other
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Revisions: 6
Last Time: 3/20/2009 3:06:01 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin