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A model for interaural time difference sensitivity in the medial superior olive (Zhou et al 2005)
This model simulates responses of neurons to interaural time difference (ITD) in the medial superior olive (MSO) of the mammalian brainstem. The model has a bipolar cell structure and incorporates two anatomic observations in the MSO: (1) the axon arises from the dendrite that receives ipsilateral inputs and (2) inhibitory synapses are located primarily on the soma in adult animals. Fine adjustment of the best ITD is achieved by the interplay of somatic sodium currents and synaptic inhibitory currents. The model suggests a mechanism for dynamically "fine-tuning" the ITD sensitivity of MSO cells by the opponency between depolarizing sodium currents and hyperpolarizing inhibitory currents.
  • Medial Superior Olive (MSO) cell Show Other
  • Neuron or other electrically excitable cell Show Other
  • Zhou Y, Carney LH, Colburn HS (2005) Show Other
yizhou@bu.edu
auditory brainstem medial superior olive neuron
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Revisions: 21
Last Time: 1/18/2014 10:34:11 PM
Reviewer: Robert A McDougal
Owner: Tom Morse - MoldelDB admin