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Allosteric gating of K channels (Horrigan et al 1999)
Calcium sensitive large-conductance K channel conductance is controlled by both cytoplasmic calcium and membrane potential. Experimental data obtained by the inside out patch method can be understood in terms of a gating scheme where a central transition between a closed and an open conformation is allosterically regulated by the state of four independent and identical voltage sensors. See paper for more and details.
  • Horrigan FT, Cui J, Aldrich RW (1999) Show Other
snwu@mail.ncku.edu.tw
neuron
Han-Dong Chang, and Jiun-Shian Wu
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