BrainPharm: Computational model - Role of KCNQ1 and IKs in cardiac repolarization (Silva, Rudy 2005) (XPP)

Computational model

Data

Name

Role of KCNQ1 and IKs in cardiac repolarization (Silva, Rudy 2005) (XPP)

Submitter name

Pipeline ID

Model File

IKs_Mar [?]

Notes

Detailed Markov model of IKs (the slow delayed rectifier K+ current) is supplied here in XPP. The model is compared to experiment in the paper. The role of IKs in disease and drug treatments is elucidated (the prevention of excessive action potential prolongation and development of arrhythmogenic early afterdepolarizations). See also modeldb accession number 55748 code and reference for more and details. This XPP version of the model reproduces Figure 3C in the paper by default. These model files were submitted by: Dr. Sheng-Nan Wu, Han-Dong Chang, Jiun-Shian Wu Department of Physiology National Cheng Kung University Medical College

Model Neurons

More Cells

Model Currents

I K Show Other
I Potassium Show Other
KCNQ1 Show Other
I_Ks Show Other

Model Receptors

Model Type

Channel/Receptor Show Other

Model Concept

Activity Patterns Show Other
Ion Channel Kinetics Show Other
Action Potentials Show Other
Heart disease Show Other
Long-QT Show Other
Markov-type model Show Other

Simulator software

XPP Show Other

Model papers

Silva J, Rudy Y (2005) Show Other

Gene

Kv1.9 Kv7.1 KCNQ1 Show Other

hg folder name (applicable when in ModelDB hg)

Region Organism

Model ID Number

Gap Junctions

Implemented by

Wu, Sheng-Nan [snwu at mail.ncku.edu.tw] Show Other
Chang, Han-Dong Show Other
Wu, Jiun-Shian [coolneon at gmail.com] Show Other

Public Submitter Email Address

Other Neuron

heart cells

Model Neurotransmitters

Ions Show Other

Other Receptor

Other Current

Other Neurotransmitter

Other Model Type

Other Concept

Other Simulator

Other Implementer

Chang, Han-Dong and Wu, Jiun-Shian

Alternative Version

Citation

Default File Notes

Other Gene

Simulation Platform ID

Has Model View

False

Component

RAM

Hide Auto-launch button

False

Run Protocols

ICG Channel Details

Species

Other categories referring to Role of KCNQ1 and IKs in cardiac repolarization (Silva, Rudy 2005) (XPP)

Revisions:	14
Last Time:	2/26/2018 11:01:05 AM
Reviewer:	Tom Morse - MoldelDB admin
Owner:	Tom Morse - MoldelDB admin